清热祛湿方加减联合西药治疗脾胃湿热型 慢性萎缩性胃炎伴肠上皮化生临床研究
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Clinical Study on Modified Qingre Qushi Prescription Combined with Western Medicine for Chronic Atrophic Gastritis Complicated with Intestinal Metaplasia of Spleen-stomach Dampness-heat Type
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    摘要:

    目的:观察清热祛湿方加减联合西药治疗脾胃湿热型慢性萎缩性胃炎(CAG) 伴肠上皮化生(IM) 的临床疗效。方法:选取96例脾胃湿热型CAG伴IM患者,按随机数字表法分为观察组和对照组各48例,观察组、对照组分别有2例、4例患者脱落。对照组给予增强胃黏膜营养、改善胃动力、抑酸、抗幽门螺杆菌治疗,观察组在对照组基础上辅以清热祛湿方加减治疗,2组均连续治疗4周。比较2组治疗前后的中医证候积分、IM分级,治疗后对比2组疗效和幽门螺杆菌转阴率。结果:治疗后,2 组中医证候积分均较治疗前降低(P<0.05),且观察组中医证候积分降低幅度大于对照组(P<0.05)。治疗后观察组IM分级较治疗前改善(Z=12.89,P<0.01),对照组IM分级与治疗前比较差异无统计学意义(Z=1.69,P>0.05),观察组治疗后IM分级优于对照组(Z=4.88,P<0.05)。观察组总有效率95.65%,高于对照组的79.55%(P<0.05)。治疗后,观察组幽门螺杆菌转阴率为92.00%,高于对照组的66.67%(P<0.05)。结论:清热祛湿方加减用于脾胃湿热型CAG 伴IM 患者的治疗中,有利于改善中医证候,减轻IM程度,促进幽门螺杆菌根治。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Qingre Qushi prescription combined with western medicine for chronic atrophic gastritis(CAG) complicated with intestinal metaplasia(IM) of spleen- stomach dampness- heat type. Methods:A total of 96 cases of patients with CAG complicated with IM of spleen-stomach dampness-heat type were divided into the observation group and the control group according to the random number table method, 48 cases in each group. There were two and four cases lost in the observation group and the control group. The control group was given treatment for enhance nutrition of intestinal mucosa,protection of gastric mucosa, acid suppression and anti-helicobacter pylori;the observation group was additionally treated with modified Qingre Qushi prescription based on the treatment of the control group. Both groups were treated for four weeks. The Chinese medicine syndrome scores and the grade of IM before and after treatment,and the curative effect and the negative rate of helicobacter pylori after treatment in the two groups were compared. Results: After treatment, the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05), and the decrease in the observation group was larger than that in the control group(P<0.05). After treatment, the grade of IM in the observation group was improved when compared that before treatment(Z=12.89,P<0.01);there was no significant difference being found in the comparison of the grade of IM in the control group before and after treatment(Z=1.69,P>0.05);the grade of IM in the observation group was better than that in the control group(Z=4.88, P<0.05). The total effective rate was 95.65% in the observation group, higher than that of 79.55% in the control group(P<0.05). After treatment, the negative rate of helicobacter pylori was 92.00% in the observation group, higher than that of 66.67% in the control group(P<0.05). Conclusion: The modified Qingre Qushi prescription in treating patients with CAG complicated with IM of spleen-stomach dampness-heat type is conductive to improving Chinese medicine syndrome, reducing IM and promoting radical treatment of helicobacter pylori.

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吴绵勇,郁银娟.清热祛湿方加减联合西药治疗脾胃湿热型 慢性萎缩性胃炎伴肠上皮化生临床研究[J].新中医,2020,52(8):69-72

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  • 在线发布日期: 2020-04-25
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