| 摘要: |
| 目的：分析万海同教授治疗缺血性脑卒中恢复期的用药规律。方法：收集2013年1月—2015年12月万海同教授治
疗缺血性脑卒中恢复期病例125例，200诊次的中药处方，采集患者临床信息，建立数据库，对药物频数、分类以及归经性味进
行描述性分析，采用SPSS24.0软件对57味高频中药进行聚类分析。结果：125例患者200诊次共使用中药127味，累计用药频次
4 745次；其中用药频次排名前七位者依次是川芎、生地黄、葛根、石斛、太子参、黄芪、水蛭；药物类别使用频次最高者是补
虚药，其次为活血化瘀药、清热药；药物归经最多者为肝经，将微寒、寒、凉归为一类“寒”，则发现药性使用频次最多者为寒
性，药味使用频次最高者是甘味。聚类分析将药物分为26类，涉及方剂有万教授自拟养阴益气活血方、补阳还五汤、镇肝熄风
汤、解语丹、天麻钩藤饮、增液汤等；涉及药对有生地黄与石斛、桃仁与红花、黄芪与太子参、玄参与麦冬、天麻与钩藤、茯苓
与白术、半夏与石菖蒲等。结论：聚类分析结果客观反映了万海同教授治疗缺血性脑卒中恢复期养阴、益气、活血法的用药规律。 |
| 关键词: 缺血性脑卒中 恢复期 数据挖掘 聚类分析 用药规律 名医经验 |
| DOI： |
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| 基金项目:国家自然科学基金项目（81630105） |
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| Study on WAN Haitong's Administration Rules of Treating Ischemic Stroke in Conva⁃lescence Based on Data Mining |
| LIU Mingxi,WANG Yu,WAN Haitong |
| () |
| Abstract: |
| Abstract： Objective： To analyze the administration rules of professor WAN Haitong in treating ischemic stroke in
convalescence. Methods：The clinical information of 125 cases of patients with ischemic stroke in convalescence treated by
professor WAN Haitong from January 2013 to December 2015 was collected，so were the Chinese herbs prescriptions in 200
visits. After setting up a database， descriptive analysis of the frequency， classification， meridian entry as well as qi and
flavorsof Chinese herbal medicines was carried out，and cluster analysis of 57 high-frequency Chinese herbal medicines was
conducted by SPSS24.0 software. Results：A total of 127 kinds of Chinese herbal medicines were used in 200 visits of 125
patients，with a cumulative frequency of administration of 4，745 times. Among them，the top seven herbs were successively
Rhizoma Chuanxiong，Radix RehmanniaeRecens，Radix PuerariaeLobatae，Caulis Dendrobii，Radix Pseudostellariae，Radix
Astragali and Hirudo. According to the classification of the effect， the most frequently used Chinese herbal medicines
were successively deficiency-supplementing medicine，blood-activating and stasis-resolving medicine and heat-clearing
medicine. The top one meridian entry of Chinese herbal medicine was the liver meridian；when we classified mild cold，cold
and cool as the same kind of cold，the nature with the highest frequency was cold，and the highest-frequency flavor was
sweet. Chinese herbal medicines used by professor WAN were classified into 26 categories by cluster analysis， involving
prescriptions such as professor WAN's self- made YangyinYiqiHuoxue prescription， BuyangHuanwu tang， ZhenganXifeng
tang， Jieyu pills， TianmaGouteng yin and Zengye tang， and couplet medicines including Radix RehmanniaeRecens and
Caulis Dendrobii， Semen Persicae and FlosCarthami， Radix Astragali and Radix Pseudostellariae， Radix Scrophulariae and
Radix Ophiopogonis，RhizomaGastrodiae and RamulusUncariae Cum Uncis，Poria and RhizomaAtractylodisMacrocephalae， as well as RhizomaPinelliae and RhizomaAcoriTatarinowii. Conclusion： The results of cluster analysis objectively show the
administration rules of professor WAN Haitong applying YangyinYiqiHuoxue method in treating ischemic stroke in
convalescence. |
| Key words: Keywords： Ischemic stroke Convalescence Data mining Cluster analysis Administration rules Experience of
famous physicians |
