Abstract：Objective：To observe the curative effect of Qushi Tongluo prescription combined with colchicine tablets for acute gouty arthritis(AGA). Methods：A total of 90 cases of AGA patients with dampness-heat accumulation syndrome were selected and divided into two groups according to the random number table method，45 cases in each group. Both groups were given oral administration of allopurinol tablets； the control group was additionally given routine dose of colchicine tablets；the observation group was additionally given oral administration of low-dose colchicine tablets combined with Qushi Tongluo prescription. Both groups were treated for eight weeks. Before and after treatment，the scores of joint pain and joint function in the two groups were compared； the levels of blood uric acid(BUA)， serum interleukin- 1β(IL- 1β) and tumor necrosis factor- α(TNF- α) were detected. The clinical effect was evaluated and the incidence of adverse reactions was recorded. Results： The total effective rate was 88.9% in the observation group and 66.7% in the control group， the difference being significant(P＜0.05). After treatment，the scores of joint pain and joint function as well as the levels of IL-1β and TNF-α in serum in the two groups were decreased when compared with those before treatment(P＜0.05，P＜0.01)；the scores of joint pain and joint function in the observation group were lower than those in the control group(P＜0.01)，and there was no significant difference being found in the comparison of IL-1β and TNF-α in serum in the two groups(P＞0.05). After treatment for four weeks and eight weeks respectively，BUA levels in the two groups were decreased when compared with those before treatment(P＜0.05)；BUA levels in the observation group were lower than those in the control group(P＜0.05). During treatment，the incidence of adverse reactions was 26.7% in the observation group and 46.7% in the control group， the difference being significant(P＜0.05). Conclusion： Qushi Tongluo prescription combined with colchicine tablets can effectively reduce the levels of BUA， IL- 1β and TNF- α in plasmain AGA patients with dampness- heat accumulation syndrome， improve their joint function， enhance the curative effect and meanwhile reduce the adverse reactions of the drugs.