Objective： To observe the clinical effect of Gongning granules combined with transcervical resection of endometrium through hysteroscope for perimenopausal abnormal uterine bleeding(AUB).Methods：A total of 170 cases of perimenopausal AUB patients were divided into the control group and the observation group according to the random number table method，85 cases in each group.Both groups were treated with transcervical resection of endometrium through hysteroscope，and the observation group was additionally treated with Gongning granules.The treatment lasted for four weeks.The therapeutic effect，recurrence，serum hemoglobin(Hb)，estradiol(E2)，follicle-stimulating hormone(FSH)， luteinizing hormone(LH)and postoperative complications in the two groups were compared.Results： After treatment，there was no significant difference in the comparison of the levels of E2，FSH and LH in the control group before and after treatment(P＞0.05).Compared with those in the control group，the levels of Hb and E2in the observation group were increased and the levels of FSH and LH were decreased，the difference being significant(P＜0.05).The incidence of complications in the observation group was 3.53%，lower than that in the control group(12.94%)，the difference being significant(P＜0.05).After six-month follow-up，the cure rate in the observation group was 98.82%，higher than that in the control group(91.76%)；the recurrence rate in the observation group was 1.18%，lower than that in the control group(8.24%)；the difference was significant(P ＜ 0.05).Conclusion：The therapy of transcervical resection of endometrium through hysteroscope combined with Gongning granules has significant effect in treating perimenopausal AUB with low recurrence rate， which can improve the ovarian function of patients and reduce postoperative complications， and is worthy of clinical promotion and application.