冠脉宁通方联合西药治疗冠心病心绞痛临床研究
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R541.4

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Clinical Study on Guanmai Ningtong Prescription Combined with Western Medicine for Angina Pectoris
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    摘要:

    目的:观察冠脉宁通方联合西药治疗冠心病心绞痛的临床疗效。方法:选择冠心病心绞痛患者83例,按随机数字表法分为观察组43例和对照组40例。2组患者入院后均给予常规西药治疗,在此基础上,观察组给予冠脉宁通方治疗,对照组给予中药安慰剂治疗,连续治疗12周后观察2组临床疗效。结果:观察组总有效率为95.35%,显著高于对照组70.00%(P<0.05)。治疗前,2组血清转化生长因子-β1(TGF-β1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清TGF-β1、IL-6、TNF-α、hs-CRP水平较治疗前降低,且观察组血清TGF-β1、IL-6、TNF-α、hs-CRP水平低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分较治疗前下降,且观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组斑块平均厚度、斑块平均数量、斑块平均面积比较,差异无统计学意义(P>0.05)。治疗后,2组斑块平均厚度、斑块平均数量、斑块平均面积较治疗前减少,且观察组斑块平均厚度、斑块平均数量、斑块平均面积低于对照组,差异均有统计学意义(P<0.05)。结论:冠脉宁通方联合西药治疗冠心病心绞痛可有效抑制炎症反应,改善冠状动脉斑块形态和临床症状,临床疗效显著,值得推广应用。

    Abstract:

    Objective:To observe the clinical effect of Guanmai Ningtong prescription combined with western medicine for angina pectoris.Methods:Selected 83 cases of patients with angina pectoris and divided them into the observation group with 43 cases and the control group with 40 cases according to the random number table.Both groups were treated with routine western medicine after admission.On this basis,the observation group was additionally given Guanmai Ningtong prescription and the control group was additionally given Chinese medicine placebo.Observed the clinical effect in the two groups after 12 weeks of continuous treatment.Results:The total effective rate in the observation group was 95.35%,being obviously higher than that of 70.00% in the control group(P< 0.05).Before treatment,there was no significant difference being found in the comparison of the levels of serum transforming growth factor- β1(TGF- β1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in the two groups(P > 0.05).After treatment,the levels of serum TGF-β1,IL-6,TNF-α and hs-CRP in the two groups were decreased when compared with those before treatment and the levels of serum TGF-β1,IL-6,TNF-α and hs-CRP in the observation group were lower than those in the control group,differences being significant(P < 0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores in the two groups(P> 0.05).After treatment,the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment and the Chinese medicine syndrome scores in the observation group were lower than those in the control group,differences being significant(P<0.05).Before treatment, there was no significant difference being found in the comparison of the average plaque thickness,average quantity of plaque and average plaque area in the two groups(P> 0.05).After treatment,the average plaque thickness,average quantity of plaque and average plaque area in the two groups were decreased when compared with those before treatment and the average plaque thickness,average quantity of plaque and average plaque area in the observation group were lower than those in the control group,differences being significant(P< 0.05).Conclusion:The application of Guanmai Ningtong prescription combined with western medicine for angina pectoris can effectively inhibit the inflammatory reactions and improve the morphology and clinical symptoms of coronary plaque,which has evident clinical effect and is worthy of promotion and application.

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唐国良.冠脉宁通方联合西药治疗冠心病心绞痛临床研究[J].新中医,2020,52(2):53-56

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  • 在线发布日期: 2020-01-14
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