活血逐瘀汤联合尼可地尔治疗微血管性心绞痛临床研究
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R541.4

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2018年河南省卫建委联合共建项目(2018020314)


Clinical Study on Huoxue Zhuyu Tang Combined with Nicorandil for Microvascular Angina
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    摘要:

    目的:观察活血逐瘀汤联合尼可地尔治疗微血管性心绞痛(MVA) 的临床疗效与安全性。方法:选取88 例MVA 患者,按随机数字表法分为对照组和观察组各44 例。2 组均给予阿司匹林、美托洛尔、瑞舒伐他汀等西药治疗,对照组同时给予尼可地尔片治疗,观察组在对照组基础上联合活血逐瘀汤治疗,2 组均以4 周为1 个疗程,连续治疗3 个疗程。比较2 组临床疗效,观察2 组治疗前后血浆内皮素-1(ET-1)、一氧化氮(NO)、高敏C-反应蛋白(hs-CRP) 水平及心绞痛发作频率、每次心绞痛持续时间、疼痛程度、中医证候评分的变化,观察不良反应发生情况。结果:观察组总有效率为95.45%,对照组总有效率为81.82%,2 组比较,差异有统计学意义(P<0.05)。治疗后,观察组血浆NO 水平高于对照组,血浆ET-1、hs-CRP 水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组心绞痛发作频率及每次心绞痛持续时间均少于对照组,疼痛程度及中医证候评分均低于对照组,差异均有统计学意义(P<0.05)。治疗期间,2 组肝肾功能均正常,未见明显不良反应。结论:活血逐瘀汤联合尼可地尔治疗MVA,可有效改善患者的内皮功能和临床症状,用药安全性高。

    Abstract:

    Abstract: Objective: To observe the clinical effect and safety of Huoxue Zhuyu tang combined with nicorandil for microvascular angina(MVA). Methods:A total of 88 cases of MVA patients were selected and divided into the control group and the observation group according to the random number table method,44 cases in each group. Both groups were treated with western medicine,for example,aspirin,metoprolol and rosuvastatin;the control group was additionally treated with nicorandil,and the observation group was additionally treated with Huoxue Zhuyu tang based on the treatment of the control group. Both groups were continuously treated for three courses,four weeks being a course. The clinical effect was compared between the two groups. The changes in levels of endothelin-1(ET-1),nitric oxide(NO),high-sensitivity C-reactive protein (hs- CRP) in plasma, the frequency of angina pectoris, the duration of each angina pectoris, the degree of pain, and Chinese medicine syndrome scores before and after treatment were observed in the two groups. The incidence of adverse reactions was observed. Results:The total effective rate was 95.45% in the observation group,and 81.82% in the control group, the difference being significant(P<0.05). After treatment, the level of NO in plasma in the observation group was higher than that in the control group, and the levels of ET- 1 and hs- CRP in plasma were lower than those in the control group, differences being significant(P<0.05). After treatment, the frequency of angina pectoris and the duration of each angina pectoris in the observation group were less than those in the control group, and the degree of pain and Chinese medicine syndrome scores were lower than those in the control group, differences being significant(P<0.05). During treatment, the liver- kidney function in the two groups were normal, and no significant adverse reaction occurred. Conclusion:The therapy of Huoxue Zhuyu tang combined with nicorandil for MVA can effectively improve endothelial function and clinical symptoms with high safety.

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何兆辉,王志谦,王国良,马光,薛永亮,滕伟,惠学志.活血逐瘀汤联合尼可地尔治疗微血管性心绞痛临床研究[J].新中医,2020,52(18):60-63

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  • 在线发布日期: 2020-09-20
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