| 摘要: |
| 目的：观察补阳还五汤对急性脑梗死患者外周血内皮祖细胞（EPCs）、血管内皮生长因子（VEGF）、基质细胞衍生因子-1（SDF-1） 水平及神经功能、日常生活活动能力的影响。方法：选取71 例急性脑梗死患者，按随机数字表法分为研究组35 例和对照组36 例。对照组给予阿司匹林肠溶片、阿托伐他汀钙片及辅助改善脑代谢和脑循环的药物治疗，研究组在对照组基础上加用补阳还五汤治疗，2 组均治疗14 天。治疗期间研究组脱落2 例，对照组脱落5 例。检测并对比2 组治疗前后外周血EPCs、VEGF 及SDF-1 水平，统计并比较2 组治疗前、治疗14 天、随访30 天及随访60 天美国国立卫生研究院卒中量表（NIHSS） 评分和改良Barthel 指数（MBI）。结果：治疗后，2 组外周血EPCs、VEGF 及SDF-1 水平均较治疗前升高（P＜0.05），研究组外周血EPCs、VEGF 及SDF-1 水平均高于对照组（P＜0.05）。治疗14 天及治疗后随访30、60 天，2 组NIHSS 评分均较治疗前降低（P＜0.05），MBI 均较治疗前升高（P＜0.05）；研究组NIHSS 评分低于同期对照组（P＜0.05），MBI 高于同期对照组（P＜0.05）。结论：补阳还五汤能改善急性脑梗死患者的神经功能缺损症状，提高其日常生活活动能力，作用机制可能与提高外周血EPCs、VEGF 及SDF-1 水平有关。 |
| 关键词: 急性脑梗死 补阳还五汤 内皮祖细胞 血管内皮生长因子 基质细胞衍生因子-1 神经功能 日常生活活动
能力 |
| DOI： |
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| 基金项目:国家自然科学基金项目（81774199）；国家自然科学基金助力基金项目（2D02019030） |
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| Effect of Buyang Huanwu Tang on Levels of EPCs， VEGF and SDF- 1 in PeripheralBlood， Neurological Function and Activities of Daily Living in Patients with AcuteCerebral Infarction |
| HOU Bonan,HUANG Shuiqing,WU You,LIANG Shunli,XU Linsheng,XU Bin |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract： Objective： To observe the effect of Buyang Huanwu tang on levels of endothelial progenitor cells(EPCs)， vascular endothelial growth factor(VEGF) and stromal cell-derived factor 1(SDF-1) in peripheral blood，neurological function
and activities of daily living in patients with acute cerebral infarction. Methods： A total of 71 cases of patients with acute
cerebral infarction were divided into the study group and the control group according to the random number table method，35
and 36 cases in each group respectively. The control group was treated with aspirin enteric- coated tablets， atorvastatin
tablets and medicines improving cerebral metabolism and cerebral circulation，and the study group was additionally treated
with Buyang Huanwu tang based on the treatment of the control group. Both groups were treated for 14 days. During
treatment， two cases of patients in the study group were lost， and five in the control group were lost. Before and after
treatment，the levels of EPCs，VEGF and SDF-1 in peripheral blood in the two groups were detected and compared. Before
treatment，on the 14th day of treatment，and on the 30th and 60th days of follow- ups respectively，the scores of National
Institutes of Health Stroke Scale(NIHSS) and Modified Barthel Index(MBI) in the two groups were counted and compared.
Results：After treatment，the levels of EPCs，VEGF and SDF-1 in peripheral blood in the two groups were increased when
compared with those before treatment(P＜0.05)，and the levels in the study group were higher than those in the control group
(P＜0.05). On the 14th day of treatment and the 30th and 60th days of follow-ups，the NIHSS scores in the two groups were
decreased when compared with those before treatment(P＜0.05)，and the MBI were increased(P＜0.05)；the NIHSS scores
in the study group were lower than those in the control group at the same period(P＜0.05)， and the MBI were higher(P＜
0.05). Conclusion： Buyang Huanwu tang for patients with acute cerebral infarction can improve symptoms of neurologic
impairment and activities of daily living，whose mechanism may be related to the increase of levels of EPCs，VEGF and SDF-
1 in peripheral blood. |
| Key words: Keywords：Acute cerebral infarction Buyang Huanwu tang Endothelial progenitor cells Vascular endothelial growth
factors Stromal cell-derived factor-1 Neurological function Activities of daily living |
