| 摘要: |
| 目的：观察小儿柴桂退热颗粒联合利巴韦林气雾剂治疗小儿急性上呼吸道感染（AURI） 的疗效及对血清超敏C-反应蛋白（hs-CRP）、免疫功能的影响。方法：将AURI 患儿100 例按数字奇偶法分为观察组与对照组各50 例，2 组患儿入院后均给予常规对症支持治疗，对照组给予利巴韦林气雾剂治疗，观察组在对照组基础上给予小儿柴桂退热颗粒治疗，疗程结束后比较2 组临床疗效及血清hs-CRP、免疫功能指标变化。结果：观察组临床治疗总有效率为96.00%，对照组临床治疗总有效率为72.00%，2 组比较，差异有统计学意义（P＜0.05）。观察组咳嗽咽痛、鼻塞流涕及发热消失时间均明显早于对照组（P＜0.05）。治疗前，2 组血清hs-CRP 水平比较，差异无统计学意义（P＞0.05），治疗后，2 组血清hs-CRP 水平较治疗前明显降低，且观察组血清hs-CRP 水平低于对照组（P＜0.05）。治疗前，2 组CD4+、CD8+、CD4+/CD8+比较，差异无统计学意义（P＞0.05），治疗后，2 组CD4+、CD4+/CD8+较治疗前上升，观察组CD4+、CD4+/CD8+明显高于对照组（P＜0.05）；2 组CD8+较治疗前明显降低，观察组CD8+明显低于对照组（P＜0.05）。治疗期间，观察组1 例患儿出现白细胞下降，对照组2 例患儿出现白细胞下降，未出现其他药物不良反应，停药1 周后白细胞恢复正常。结论：小儿柴桂退热颗粒联合利巴韦林气雾剂治疗小儿AURI 疗效确切，可有效缓解患儿临床症状体征，抑制炎症反应，提高免疫力，且药物安全性高。 |
| 关键词: 急性上呼吸道感染 小儿 小儿柴桂退热颗粒 利巴韦林气雾剂 免疫功能 |
| DOI： |
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| 基金项目: |
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| Observation of Xiao'er Chaigui Tuire Granules Combined with Ribavirin Aerosol forAcute Upper Respiratory Infection in Children and Its Effect on hs-CRP in Serum andImmune Function |
| WANG Li'na |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the curative effect of Xiao'er Chaigui Tuire granules combined with ribavirin aerosol for
acute upper respiratory infection(AURI) in children and its effect on high-sensitivity C-reactive protein(hs-CRP) in serum and
immune function. Methods： A total of 100 cases of AURI children were divided into the observation group and the control
group according to the odd- even number grouping method， 50 cases in each group. Both groups were given routine
symptomatic and supportive treatment after admission；the control group was given ribavirin aerosol；the observation group
was additionally given Xiao'er Chaigui Tuire granules based on the treatment of the control group. After treatment，the clinical
effect and the changes in hs-CRP in serum and immune function indexes were compared between the two groups. Results：
The total clinical effective rate was 96.00% in the observation group and 72.00% in the control group，the difference being
significant(P＜0.05). The disappearance time of cough and sore throat，nasal obstruction and discharge，as well as fever in
the observation group was significantly earlier than that in the control group(P＜0.05). Before treatment， there was no
significant difference being found in the comparison of hs-CRP level in serum between the two groups(P ＞ 0.05). After
treatment，the hs-CRP levels in serum in the two groups were significantly decreased when compared with those before
treatment， and the level in serum in the observation group was lower than that in the control group(P＜0.05). Before
treatment，there was no significant difference being found in the comparison of the values of CD4+，CD8+ and CD4+/CD8+
between the two groups(P＞0.05). After treatment， the values of CD4 + and CD4 +/CD8 + in the two groups were increased
when compared with those before treatment， and the two values in the observation group were significantly higher than
those in the control group(P＜0.05)；the CD8 + values in the two groups were significantly decreased when compared with
those before treatment，and the value in the observation group was significantly lower than that in the control group(P＜0.05).
During treatment，there was one cases of leukocyte decrease in the observation group and two cases in the control group，
and no adverse reactions of other medicine occurred. After one- week drug withdrawal， leukocytes returned to normal.
Conclusion： The therapy of Xiao'er Chaigui Tuire granules combined with ribavirin aerosol has defined curative effect in
treating AURI in children， which can effectively relieve their clinical syndromes and signs， inhibit inflammatory response，
and improve immunity with high medicine safety. |
| Key words: Keywords： Acute upper respiratory infection Children Xiao'er Chaigui Tuire granules Ribavirin aerosol Immune
function |
