| 摘要: |
| 目的：观察葛根注射液辅助治疗对急性心肌梗死患者心功能及血浆内皮素-1 （ET-1）、脑钠肽（BNP） 水平的影响。方法：选取94 例急性心肌梗死患者为研究对象，按随机数字表法分为观察组和对照组各47 例。对照组行常规溶栓、经皮冠脉介入术（PCI） 治疗，PCI 术后给予阿司匹林肠溶片治疗，观察组在对照组基础上给予葛根注射液治疗，治疗7 周。比较2 组临床疗效及治疗前后心功能指标，血浆ET-1、血浆BNP 水平。结果：观察组总有效率为91.49%，对照组总有效率为82.98%，2 组比较，差异无统计学意义（χ2=1.529，P＞0.05）。治疗后，2 组左室射血分数（LVEF）、心室短轴缩短率（FS） 均较治疗前升高（P＜0.05），左室舒张末期内径（LVDd） 均较治疗前缩小（P＜0.05）；观察组LVEF、FS 均高于对照组（P＜0.05），LVDd 小于对照组（P＜0.05）。治疗后，2 组血浆ET-1、BNP 水平均较治疗前下降（P＜0.05），观察组血浆ET-1、BNP 水平均低于对照组（P＜0.05）。结论：葛根注射液辅助治疗急性心肌梗死，可以改善患者的心功能，降低其血浆ET-1 及BNP 水平。 |
| 关键词: 急性心肌梗死 葛根注射液 心功能 内皮素-1 脑钠肽 |
| DOI： |
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| 基金项目: |
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| Effect of Puerarin Injection on Heart Function and Levels of ET- 1 and BNP in Plasmain Patients with Acute Myocardial Infarction |
| CAI Xiaohang,LI Zheng,MA Jinxia |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the effect of puerarin injection on heart function and levels of endothelin- 1(ET-1) and
brain natriuretic peptide(BNP) in plasma in patients with acute myocardial infarction. Methods：A total of 94 cases of patients
with acute myocardial infarction were selected as the study objects， and were divided into the observation group and the
control group according to the random number table method， 47 cases in each group. The control group was treated with
routine thrombolysis and percutaneous coronary intervention(PCI)， followed by aspirin enteric- coated tablets， and the
observation group was additionally treated with puerarin injection based on the treatment of the control group. Both groups
were treated for seven weeks. The heart function indexes and levels of ET-1 and BNP in plasma before and after treatment as
well as the clinical effect in the two groups were compared. Results：The total effective rate was 91.49% in the observation
group and 82.98% in the control group； there was no significant difference between the two groups(χ 2=1.529， P＞0.05).
After treatment， the left ventricular ejection fraction(LVEF) and fraction shortening(FS) in the two groups were increased
when compared with those before treatment(P＜0.05)，and left ventricular end- diastolic diameter(LVDd) were reduced(P＜
0.05)；LVEF and FS in the observation group were higher than those in the control group(P＜0.05)，and LVDd was smaller(P＜
0.05). After treatment， the contents of ET- 1 and BNP in plasma in the two groups were decreased when compared with
those before treatment(P＜0.05)，and the contents in the observation group were lower than those in the control group(P＜
0.05). Conclusion：Puerarin injection in adjuvant treatment for patients with acute myocardial infarction can improve the heart
function and reduce the levels of ET-1 and BNP in plasma. |
| Key words: Keywords：Acute myocardial infarction Puerarin injection Heart function Endothelin-1 Brain natriuretic peptide |
