| 摘要: |
| 目的：观察海桐皮汤治疗膝骨性关节炎（KOA） 的临床疗效。方法：将KOA 患者90 例随机分为对照组和治疗组，每组45 例。对照组采用玻璃酸钠关节注射液治疗，治疗组在对照组的基础上加用海桐皮汤熏洗治疗。观察比较2 组治疗前后患者美国特种外科医院（HSS） 膝关节疼痛、功能评分，观察2 组治疗前后膝关节液白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α） 与基质金属蛋白酶-13（MMP-13） 水平变化；比较2 组总体临床疗效。结果：总有效率治疗组为88.89%，对照组为68.89%，2 组比较，差异有统计学意义（P＜0.05）。治疗后2 组膝关节HSS 疼痛评分、功能评分均较治疗前升高（P＜0.05），且治疗组两项评分均高于对照组（P＜0.05）。治疗后，2 组关节液炎症因子IL-1β、TNF-α 及MMP-13 水平均较治疗前明显降低（P＜0.05），且治疗组上述各项指标均明显低于对照组（P＜0.05）。结论：关节腔内注射玻璃酸钠联合海桐皮汤治疗KOA，可有效降低关节液内炎症因子水平，减轻关节疼痛，改善膝关节功能，疗效优于单纯西药治疗。 |
| 关键词: 膝骨性关节炎 海桐皮汤 玻璃酸钠 熏洗 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Haitongpi Tang for Knee Osteoarthritis |
| LAN Zijiang,MAO Qi,WU Yuanyuan,HU Zhao |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the clinical effect of Haitongpi tang for knee osteoarthritis(KOA). Methods：A total of 90
cases of KOA patients were randomly divided into the control group and the treatment group，45 cases in each group. The
control group was treated with sodium hyaluronate for intra- articular injection， and the treatment group was additionally
treated with Haitongpi tang based on the treatment of the control group. Before and after treatment，the scores of pain and
function of knee joint in Hospital for Special Surgery(HSS) in the two groups were compared； the changes in levels of
interleukin-1β(IL-1β)，tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-13(MMP-13) in knee joint fluid in the
two groups were observed. After treatment， the total clinical effect in the two groups was compared. Results： The total
effective rate was 88.89% in the treatment group and 68.89% in the control group，the difference being significant(P＜0.05).
After treatment，the scores of pain and function of knee joint in HSS in the two groups were increased when compared with
those before treatment(P＜0.05)，and the two scores in the treatment group were higher than those in the control group(P＜
0.05). After treatment，the levels of IL-1β，TNF-α and MMP-13 in inflammatory factors in synovial fluid in the two groups
were significantly decreased when compared with those before treatment(P＜0.05)，and the indexes in the treatment group
were significantly lower than those in the control group(P＜0.05). Conclusion：The therapy of sodium hyaluronate for intraarticular
injection combined with Haitongpi tang for KOA can effectively reduce the levels of inflammatory factors in synovial
fluid，relieve joint pain and improve knee joint function，whose curative effect is better than that of simple western medicine. |
| Key words: Keywords：Knee osteoarthritis Haitongpi tang Sodium hyaluronate Fumigation and washing |
