中西医结合治疗慢性阻塞性肺疾病肺气肿表型39例临床观察
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R563.9

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Clinical Observation on 39 Cases of Integrated Chinese and Western Medicine for Chronic Obstructive Pulmonary Disease with Emphysema Phenotype
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    摘要:

    目的:观察人参补肺饮联合西医疗法治疗慢性阻塞性肺疾病(COPD)肺气肿表型的临床疗效。方法:将78例患者按随机数字表法分为2组各39例。对照组给予异丙托溴铵气雾剂喷雾吸入、茶碱缓释片口服。治疗组在对照组基础上加用人参补肺饮。均治疗16周。治疗前后进行COPD患者自我评估测试问卷(CAT)、圣乔治呼吸问卷(SGRQ)和肺肾气阴两虚证评分,进行肺功能检查,并进行气流受限的程度肺功能评估。结果:经秩和检验,治疗组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后肺功能分级提示治疗组患者气流受限严重程度轻于对照组,经秩和检验,差异有统计学意义(P<0.05)。治疗后,2组1s用力呼气容积(FEV1)、FEV1%较治疗前有所升高(P<0.05)。治疗后治疗组FEV1、FEV1%均高于对照组(P<0.05)。治疗后2组SGRQ量表呼吸症状、活动能力和疾病影响3个维度和SGRQ总分均下降(P<0.01)。治疗后治疗组SGRQ量表各个维度评分和总分均低于对照组(P<0.01)。结论:加用人参补肺饮的中西医结合疗法可以减轻肺气肿表型COPD的临床症状和气流受限严重程度,改善肺功能,提高患者的生活质量,综合疗效显著。

    Abstract:

    Objective:To observe the clinical effect of Renshen Bufei drink combined with western medicine therapy for chronic obstructive pulmonary disease(COPD)with emphysema phenotype.Methods:Divided 78 cases of patients into two groups randomly,39 cases in each group.The control group received the inhalation of ipratropium bromide aerosol and the oral administration of theophylline sustained release tablets,while the treatment group additionally received Renshen Bufei drink.The treatment for both groups lasted for 16 weeks.Before and after treatment,scored COPD assessment test(CAT),St.George’s respiratory questionnaire(SGRQ)and syndrome of yin-qi deficiency in lung and kidney,conducted pulmonary function test,and evaluated pulmonary function according to the severity of airflow limitation.Results:After rank sun test,the clinical effect in the treatment group was better than that in the control group,difference being significant(P<0.05).After treatment,the grading of pulmonary function indicated that the severity of airflow limitation in the treatment group was lower than that in the control group,difference being significant(P<0.05).After treatment,forced expiratory volume in one second(FEV1)and FEV1%in both groups were higher than those before treatment(P<0.05); FEV1and FEV1%in the treatment group were respectively higher than those in the control group(P<0.05).After treatment,the total scores and scores of SGRQ from three dimensions of respiratory symptoms,activity ability and disease influence in both groups were decreased(P<0.01);the total score and scores from each dimension in the treatment group were all lower than those in the control group(P<0.01).Conclusion:The additional application of Renshen Bufei drink based on western medicine therapy can alleviate clinical symptoms and the severity of airflow limitation in COPD with emphysema phenotype,improve pulmonary function and elevate the quality of life of patients,of which the comprehensive clinical effect is significant.

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牛建旭,王忠太.中西医结合治疗慢性阻塞性肺疾病肺气肿表型39例临床观察[J].新中医,2018,50(12):75-78

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  • 在线发布日期: 2018-12-09
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