扎里奴思方对脑梗死患者血管内皮功能的影响
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R743.3

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宁夏高等教育科研项目 (NGY2015087)


Zhali Nusi Prescripion Has Effect on Vascular Endothelial Function in Patients with Cerebral Infarction
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    摘要:

    目的:检测急性脑梗死患者使用扎里奴思方前后颈动脉内中膜厚度(IMT)、血管内皮依赖性舒张功能(FMD)、血清一氧化氮(NO)和血管内皮素-1(ET-1)含量,观察扎里奴思方对急性脑梗死血管内皮功能的影响并阐明其作用机制。方法:选择动脉粥样硬化性脑梗死患者120例,随机分为2组各60例,2组均常规予以内科基础治疗,药物组加用扎里奴思方,每天1剂。运用美国国立卫生研究院卒中量表(NIHSS)评价用药前及用药12周后患者神经功能缺损程度;彩色超声诊断仪测定IMT;计算反应性充血后FMD;硝酸还原酶法测定血清NO水平;放免法测定血浆ET-1水平。结果:与治疗前比较,治疗后2组NIHSS评分均显著降低,差异均有统计学意义(P<0.01);与对照组比较,药物组患者NIHSS评分明显降低,差异有统计学意义(P<0.05)。与治疗前比较,治疗后2组NO、FMD水平均明显升高,ET-1、IMT水平明显降低,差异均有统计学意义(P<0.01,P<0.05);与对照组治疗后比较,药物组NO、FMD水平均明显升高,ET-1、IMT水平均显著降低,差异均有统计学意义(P<0.05,P<0.01)。结论:扎里奴思方治疗脑梗死疗效肯定,其作用机制可能与改善血管内皮功能有关。

    Abstract:

    Objective:To detect intima-media thickness(IMT)in carotid,endothelium-dependent dilation function(FMD),and the content of nitric oxide(NO)in serum and vascular endothelin-1(ET-1)in patients with acute cerebral infarction before and after they were given Zhali Nusi prescripion,and observed the effect of Zhali Nusi prescripion on the vascular endothelial function of acute cerebral infarction and elaborated its mechanism.Methods:Selected 120 patients with atherosclerotic cerebral infarction and randomly divided them into two groups,60 cases in each group.The two groups were routinely given basic treatment of internal medicine.The drug group additionally received Zhali Nusi prescripion,one dose per day.Evaluated the degree of neurologic function deficits by using national institutes of health stroke scale(NIHSS)before and 12 weeks after administration of drugs; detected IMT by applying color ultrasonic diagnostic apparatus; calculated FMD after reactive hyperemia;determined the level of NO in serum by nitrate reductase assay;measured the level of ET-1 in plasma by radioimmunoassay.Results:Compared with that before treatment,the NIHSS scores of the two groups after treatment were significantly decreased,difference being significant(P<0.01);compared with that in the control group,the NIHSS scores of patients in the drug group were evidently decreased,difference being significant(P<0.05).Compared with those before treatment,the levels of NO and FMD in the two groups were obviously increased after treatment,and the levels of ET-1 and IMT were clearly decreased,differences being significant(P<0.05,P<0.01).Compared with those in the control group after treatment,the levels of NO and FMD in the drug group were significantly increased,and the levels of ET-1 and IMT were markedly decreased,difference being significant(P<0.05,P<0.01).Conclusion:The application of Zhali Nusi prescripion has definite effect in treating cerebral infarction.Its mechanism may be related to the action of improving vascular endothelial function.

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刘会贤,周凌,王季春,刘敬霞.扎里奴思方对脑梗死患者血管内皮功能的影响[J].新中医,2018,50(12):72-75

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  • 在线发布日期: 2018-12-09
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