Objective： To observe the clinical effect of Shengjing powder II for patients with oligospermia and asthenospermia with kidney-yang deficiency syndrome.Methods：Divided 72 cases of patients with oligospermia and asthenospermia with kidney-yang deficiency syndrome into two groups randomly，36 cases in each group.The control group was given the oraladministration of levocarnitine，vitamin E and zinc gluconate for treatment，while the treatment group was given the oral administration of Shengjing powder II for treatment.The treatment for both groups lasted for 3 months.Before treatment and after treatment for 3 months，detected testosterone(T)，luteinizing hormone(LH)，follicle-stimulating hormone(FSH)，semen voume，spermdensity and spermmotility of patients in both groups，and compared the clinical effect in both groups before and after treatment.Results：After treatment，the totaleffective rate was 86.11%in the treatment group and 63.89%in the control group，difference being significant(P ＜ 0.05).After treatment，the levels of sex hormone，semen volume，spermdensity and spermmotility in both groups were significantly improved when comparing with those before treatment(P ＜ 0.01，P ＜ 0.05)，and each index value in the treatment group was better than that in the control group(P ＜0.01，P ＜ 0.05).Conclusion：Shengjing powder IIcan effectively promote the levels of sex hormone，semen volume，spermdensity and spermmotility of patients with oligospermia and asthenospermia with kidney-yang deficiency syndrome，which has the significant clinicaleffect.