Objective：To observe the clinicaleffect of Feikang prescription combined with western medicine for syndrome of qi deficiency of spleen and lung in the stable stage of Chronic Obstructive Pulnonary Disease(COPD).Methods：Divided patients who met the inclusion criteria into the Feikang group and the control group randomly.The Feikang group was given Feikang prescription and tiotropiumbromide inhalation powder for treatment，while the control group received tiotropiu mbromide inhalation powder for treatment.The treatment for both groups lasted for 3 months.Observed the changes of scores of Chinese medicine syndromes，simp lified St George's respiratory questionnaire(SGRQ)，6-min walk distance(6MWD)and expression of interleukin(IL)-1β，tumour necrosis factor(TNF-α )，IL-6 and IL-17 in the induced sputumin both groups.Results： After treatment， comparing each symptomscore in the Feikang group with that before treatment， there were significant differences being found(P ＜ 0.05)；comparing the scores of cough，expectoration and wheezing in the control group with those before treatment，there was significant difference being found(P ＜ 0.05)， and there was no significant differences being found in the other indexes.Except the scores of cough and wheezing，comparing the value differences of the other symptomscores in both groups before and after treatment，there were significant differences being found(P ＜ 0.05).Simplified SGRQ symptomscores，activity scores，scores of disease influence and the total scores in both groups were lower than those before treatment(P ＜ 0.05)；the value differences of SGRQ symptomscores and activity scores in the Feikang group before and after treatment were all higher than those in the control group( P ＜0.05).6MWD in the Feikang group was increased when comparing with that before treatment(P ＜ 0.05)，and the value difference in the Feikang group before and after treatment was higher than that in the controlgroup( P ＜0.05).the levels of IL-1β，TNF-α，IL-6 and IL-17 in the induced sputumof both groups were lower than those before treatment(P ＜ 0.05)；the value differences of levels of TNF-α and IL-17 in the Feikang group before and after treatment were both higher than those in the controlgroup( P ＜0.05).Conclusion：Feikang prescription combined with western medicine can significantly improve the clinical symptoms of patients with syndrome of qideficiency of spleen and lung in the stable stage of COPD，enhance the quality of life，and decrease the levels of inflammatory factors including IL-1β，TNF-α，IL-6 and IL-17 in the induced sputumof patients.It is considered that the functionalmechanismof its clinical effectmay be related to reducing inflammatory factors in airway so as to relieve the inflammatory reactions in airway.