防感香佩包成分分析及其防治儿童上呼吸道感染作用机理研究
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R725.6

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广东省中医药局科研项目(20161197)


Composition Analysis of An ti-influenza Sachets and Study on its Functional Mechanism of Preven ting and Treating Upper Respiratory Tract In fection in Child ren
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    摘要:

    目的:提取分离防感香佩包中挥发油成分,明确最佳提取条件,分析挥发性成分组成,探索防感香佩包临床疗效可能的作用机理。方法:采用水蒸气蒸馏法将37包防感香佩包进行提取分离,收集挥发油,分别对浸泡时间(1、2、3、4 h)、提取时间(1、2、3、4、5 h)、料液比(5、10、20、30倍) 及提取次数(1、2、3次) 进行多因素多水平考察。确定高出油率的提取分离条件,通过GC-MS对挥发油化学成分进行定性和半定量分析。结果:收集防感香佩包挥发油成分的最佳提取条件为:5倍体积水浸泡1 h,提取3次,3 h/次。挥发油中主要成分为细辛醚类(43%)和倍半萜类(50%)。结论:防感香佩包挥发油成分获得性良好,主要成分明确,其防治儿童上呼吸道感染反复发作作用机理可能与细辛醚类及倍半萜有关。

    Abstract:

    Objective:To extract and separate the volatile oil fromanti-influenza sachets,clarify the optimal extraction conditions,analyze the compositions of its volatile oil,and discover the probable functional mechanism of the clinical effect of anti-influenza sachets.Methods:Extracted,separated and collected the volatile oil from37 anti-influenza sachets by stea mdistillation.Multi factor and multi level study of the soaking time(1,2,3,4 h),extraction time(1,2,3,4,5 h),solid-liquid ratio(5,10,20,30 times)and extraction times(1,2,3 times)respectively.Ascertained the high-oil-yield conditions of extraction and separation.Qualitative and semi-quantitative analysis of chemical constituents of volatile oilwas carried out by gas chromatography-mass spectrometry(GC-MS).Results:The optimal extraction conditions of collecting the volatile oil fromanti-influenza sachets was soaking with water of 5-time volume for 1 h and extraction for 3 times,once every 3 hours.The main compositions of volatile oil were asar one(43%)and sesquiter pene(50%).Conclusion:The volatile oil of anti-influenza sachets has good availability together with clear composition,and its functional mechanism of preventing and treating recurrent upper respiratory tract infections in children may be related to asarone and sesquiterpene.

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钱丹,韦力,郑梓培,黄向红.防感香佩包成分分析及其防治儿童上呼吸道感染作用机理研究[J].新中医,2018,50(7):12-14

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  • 在线发布日期: 2018-07-09
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