强骨活血汤联合鲑鱼降钙素治疗骨质疏松性股骨颈骨折临床观察
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R683.42

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浙江省自然科学基金资助项目(LY14H120137)


Clinical Observation of Qianggu Huoxue Tang Combined with Salmon Calcitonin for Osteoporotic Femoral Neck Fracture
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    摘要:

    目的:观察强骨活血汤联合鲑鱼降钙素对老年人骨质疏松性股骨颈骨折患者血清骨钙素、胰岛素样生长因子和骨密度的影响。方法:将收治的老年人骨质疏松性股骨颈骨折患者17 2例,采用随机字母表法分为观察组与对照组各86例。对照组采用鲑鱼降钙素治疗,观察组在对照组基础上给予强骨活血汤治疗,比较2组患者临床症状改善情况、临床疗效、近期康复情况、血清骨钙素、胰岛素样生长因子、骨密度及安全性。结果:2组临床疗效比较,总有效率观察组9 8.84%,高于对照组89.53%,差异有统计学意义(P<0.05)。与治疗前比较,治疗后观察组与对照组中医证候积分均降低,且观察组低于对照组,2组血清骨钙素、胰岛素样生长因子及骨密度均升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。观察组消肿时间、愈合时间及开始下床活动时间均明显短于对照组,差异均有统计学意义(P<0.05)。2组患者均无明显不良反应。结论:强骨活血汤联合鲑鱼降钙素治疗老年人骨质疏松性股骨颈骨折患者临床疗效良好,可有效缩短康复时间,提高骨钙素水平与胰岛素样生长因子水平,增加骨密度,且安全性高。

    Abstract:

    Objective: To observe the effect of Qianggu Huoxue tang combined with salmon calcitonin on serum osteocalcin,insulin-like growth factor and bone mineral density of patients with senile osteoporotic femoral neck fracture.M e th o d s:Divided 172 cases of patients with senile osteoporotic femoral neck fracture admitted in our hospital into two groups according to random number table method,86 cases in each group.The control group received salmon calcitonin for treatment,while the observation group additionally received Qianggu Huoxue tang based on the treatment of the control group.Compared the improvement of the clinical symptoms, the clinical effect, recent rehabilitation condition, serum osteocalcin,insulin-like growth factor,bone mineral density and safety in the two groups.Results:The total effective rate was 98.84%in the observation group,higher than that of 89.53%in the control group,the difference being significant(P <0.05).Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the scores in the observation group were lower than those in the control group;levels of serum osteocalcin,insulin-like growth factor and bone mineral density in the two groups were increased when compared with those before treatment,and the above three levels in the observation group were higher than those in the control group,differences being significant(P<0.05).The detumenscence time,healing time and ambulation time in the observation group were obviously shorter than those in the control group,differences being significant(P<0.05).No obvious adverse reaction was found in the two groups.C o n c lu s io n:The therapy of Qianggu Huoxue tang combined with salmon calcitonin has significant effect in treating patients with senile osteoporotic femoral neck fracture, which can effectively shorten the rehabilitation time, improve levels of osteocalcin and insulin-like growth factor and increase bone mineral density with high safety.

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于乐惠,陈剑强.强骨活血汤联合鲑鱼降钙素治疗骨质疏松性股骨颈骨折临床观察[J].新中医,2018,50(6):105-108

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  • 在线发布日期: 2018-06-05
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