化痰祛瘀汤治疗脑梗死急性期临床观察
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R743

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Clinical Observation on Huatan Quyu Tang for Cerebral Infarction of Acute Stage
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    摘要:

    目的:观察化痰祛瘀汤治疗脑梗死急性期的临床疗效,及对患者凝血-纤溶系统和神经功能恢复的影响。方法:选取98例脑梗死急性期患者,按随机数字表法分为观察组和对照组,每组49例。对照组采用常规西药治疗,观察组在对照组基础上加服化痰祛瘀汤。治疗2周后观察患者症状体征及神经功能的改善情况,分析治疗效果,记录凝血-纤溶系统各项指标的变化。结果:观察组总有效率91.84%,对照组总有效率77.55%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状体征及美国国立卫生研究院卒中量表(NIHSS)评分均较治疗前降低(P<0.05),观察组症状体征及NIHSS评分均低于对照组(P<0.05)。治疗后,2组血浆D-二聚体(D-D) 及纤溶酶原激活物抑制剂-1(PAI-1) 水平均降低(P<0.05),血浆组织型纤溶酶原激活物(tPA)水平均升高(P<0.05),观察组3项凝血-纤溶系统相关指标升高或降低幅度均大于对照组(P<0.05)。结论:化痰祛瘀汤联合常规西药治疗脑梗死急性期患者,可有效改善症状体征,促进纤溶和神经功能恢复,减少血栓形成。

    Abstract:

    Objective:To observe the clinical effect of Huatan Quyu tang for cerebral infarction of acute stage and its effect on the coagulation-fibrinolysis system and neurological function recovery of patients.Methods:Selected 98 cases of patients with cerebral infarction of acute stage,and divided them into the observation group and the control group according to the random number table method,49 cases in each group.The control group was treated with routine western medicine,while the observation group was additionally given Huatan Quyu tang based on the treatment of the control group.After two weeks of treatment,observed the improvement of symptoms,signs and neurological function,analyzed the therapeutic effect,and recorded the changes of each index of coagulation-fibrinolysis system.Results:The total effective rate was 91.84%in the observation group and was 77.55%in the control group,the difference being significant(P<0.05).After treatment,scores of the symptoms,signs and NIH stroke scale(NIHSS)were decreased when compared with those before treatment(P<0.05).Scores of the symptoms,signs and NIHSS in the observation group were lower than those in the control group(P < 0.05).After treatment,levels of the plasma D-dimer(D-D)and the plasminogen activator inhibitor-1(PAI-1)in the two groups were decreased(P < 0.05),while levels of the plasma tissue plasminogen activator(tPA)in the two groups were increased(P<0.05).The increase or the decrease of three relevant indexes of coagulation-fibrinolysis system in the observation group was greater than that of control group(P<0.05).Conclusion:The therapy of Huatan Quyu tang combined with routine western medicine for patients with cerebral infarction of acute stage can effectively improve the symptoms and signs,promote fibrinolys is and neurological function recovery,and reduce thrombosis.

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王羡强.化痰祛瘀汤治疗脑梗死急性期临床观察[J].新中医,2018,50(6):80-82

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  • 在线发布日期: 2018-06-05
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