张学文治疗高血压病用药规律研究
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R544.1

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陕西省中医药管理局项目(LCPT035);陕西省科技厅项目(2016SF-372)


Study on the Medication Rule of ZHANG Xuewen for the Treatment of Hypertension
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    摘要:

    目的:运用关联规则Apriori算法探讨张学文教授辨治高血压病的用药规律。方法:选取张学文教授治疗高血压病的病例147例,共162首方剂,借助中医传承辅助平台,利用频次分析、关联规则、复杂系统熵聚类分析等数据挖掘方法进行分析,确定处方中各种药物的使用频次及药物之间的关联规则。结果:证候以肝热血瘀证为首;常用药物有天麻、川牛膝、丹参、菊花等,甘味药最多,共1 063次,寒性药物占总频次的62.67%。基于熵层次聚类法提取组合出治疗高血压病的新处方共15首。结论:张学文教授从肝以热瘀论治高血压病,疗效确切。

    Abstract:

    Objective:To use the Apriori algorithm of association rules to discuss the medication rule of Professor ZHANG Xuewen for hypertension based on syndrome differentiation.Methods:Selected 147 cases of hypertension which Professor ZHANG treated,162 prescriptions in total.With the aid of Chinese medicine inheritance support platform,the data mining methods were adopted to analyze the prescriptions, such as the method of frequency analysis, association rules and complex system entropy cluster analysis,so as to determine the frequency of use of various medicines in the prescriptions and the association rule among medicines themselves.Results:The medicines mainly manifested as the liver heat and blood stasis syndrome;the commonly used medicines included rhizoma gastrodiae,radix cyathulae, salviae miltiorrhizae and Chrysanthemi.The highest frequency of use was sweet medicines,1 063 times in total,and the cold medicines accounted for 62.67% of the total frequency.Based on the unsupervised complex system entropy cluster analysis,fifteen new prescriptions for hypertension were selected.Conclusion:The treatment of Professor ZHANG Xuewen with the theory of heat and stasis by liver-based therapy for hypertension has exact curative effect.

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周海哲,严亚锋,李军.张学文治疗高血压病用药规律研究[J].新中医,2018,50(6):33-38

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  • 在线发布日期: 2018-06-05
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