关节炎方治疗膝关节骨性关节炎临床研究
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R684.3

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Clinical Study of Arthritis Prescription for Knee Osteoarthritis
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    摘要:

    目的:观察关节炎方治疗膝关节骨性关节炎的临床疗效。方法:将符合纳入标准的膝关节骨性关节炎患者128例随机分为观察组及对照组各64例,给药采用单盲试验,对照组予双醋瑞因胶囊治疗,观察组予关节炎方治疗;疗程均为3月,检测患膝关节液的白细胞介素-1β(IL-1β)含量,采用疼痛视觉模拟评分法(VAS)评估膝骨关节疼痛,活动与疼痛的关系及功能障碍采用西安大略麦马斯特大学(WOMAC)骨关节炎指数,观察治疗前、治疗3月后分别检测血、尿、粪便常规及心、肝、肾功能检查,记录胃肠道反应情况。结果:总有效率观察组81.25%,对照组82.81%,2组比较,差异无统计学意义(P<0.05)。治疗后,2组疼痛VAS评分及WOMAC骨关节炎指数评分、膝关节液IL-1β的含量分别与治疗前比较,均有降低,膝关节的屈伸活动度增大,差异均有统计学意义(P<0.05),2组间各指标分别比较,差异均无统计学意义(P<0.05)。结论:关节炎方治疗膝关节骨性关节炎能获得与双醋瑞因治疗膝关节骨性关节炎同样的临床疗效,延缓膝关节骨性关节炎的病情进展,提高患者的生活质量。

    Abstract:

    Objective:To observe the clinical effect of arthritis prescription for knee osteoarthritis.Methods:Divided 128 cases of patients with knee osteoarthritis who met the inclusion criteria into the observation group and the control group randomly,64 cases in each group.Drugs were administered by a single blind test.The control group was given diacerein capsules for treatment,while the observation group was given arthritis prescription for treatment.The courses of treatment were both three months.Detected the content of interleukin-1β(IL-1β)of synovial fluid in lesioned knees,evaluated pain of knee joint by means of pain visual analogue scale(VAS),and evaluated relationships between activity and pain and disfunction by using Western Ontario and McMaster University(WOMAC)osteoarthritis index.Respectively observed blood routine,urine routine, stool routine and functions of heart, liver and kidney before treatment and after 3 months of treatment, and recorded gastrointestinal reactions.Results:The total effective rate was 81.25%in the observation group and 82.81%in the control group,difference being insignificant(P<0.05).After treatment,compared scores of pain VAS and WOMAC osteoarthritis index and content of IL-1β in knee joint fluid in two groups with those before treatment,these indexes all showed an evident decrease,while the flexion and extension range of motion of knee joint was increased,differences being significant(P<0.05).There were no significant difference being found in the comparisons of those indexes in the two groups(P<0.05).Conclusion:The therapy of arthritis prescription for knee osteoarthritis has the same clinical effect as diacerein capsules for knee osteoarthritis,and it can delay the progress of this disease and improve the quality of life of patients.

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黄永青,邵敏,徐绍俊,姜涛,陈庆真,汪钦生.关节炎方治疗膝关节骨性关节炎临床研究[J].新中医,2018,50(5):104-108

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  • 在线发布日期: 2018-05-03
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