血府逐瘀胶囊联合西药治疗老年高血压临床研究
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R544.1

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Clinical study of Xuefu Zhuyu Capsules Combined with Western Medicine for Senile Hypertension
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    摘要:

    目的:观察血府逐瘀胶囊联合西药治疗老年高血压患者的临床疗效。方法:将116例心血瘀阻型老年高血压患者随机分为对照组和观察组各58例,2组患者均服用苯磺酸氨氯地平片和厄贝沙坦片进行治疗,观察组加用血府逐瘀胶囊,2组均连续治疗12月,比较2组患者治疗前后的临床症状积分、颈动脉内中膜厚度(IMT),观察临床疗效及用药安全性等。结果:治疗后,观察组总有效率94.83%,对照组总有效率75.86%,2组比较,差异有统计学意义(P<0.05)。2组头痛、眩晕、胸闷、心悸、气短积分均较治疗前下降,差异均有统计学意义(P<0.05);观察组各项症状积分均低于对照组,差异均有统计学意义(P<0.05)。观察组治疗12月后,颈动脉IMT较治疗前下降,差异有统计学意义(P<0.05),与对照组比较,差异亦有统计学意义(P<0.05)。2组患者均未出现严重的不良反应。结论:采用血府逐瘀胶囊联合西药治疗心血瘀阻型老年高血压患者可有效改善临床症状,提高临床疗效,并能减少颈动脉IMT,对减少心脑血管事件的发生具有十分重要的意义。

    Abstract:

    Objective:To observe the clinical effect of Xuefu Zhuyu capsules combined with western medicine for senile hypertension.Methods:Divided 116 cases of patients with senile hypertension with heart blood stasis type into the control group and the observation group randomly,58 cases in each group.Both groups received amlodipine besylate tablets and irbesartan tablets for treatment,while the observation group additionally received Xuefu Zhuyu capsules.Both groups continuously received treatment for 12 months.Compared changes of clinical symptoms score and carotid intima-media thickness(IMT)of patients in both groups before and after treatment.Observed clinical effect,drug safety and so on.Results:After treatment,the total effective rate was 94.83%in the observation group and 75.86%in the control group,the difference being significant(P < 0.05).Scores of headache,vertigo,chest distress,palpitation and shortness of breath in both groups were decreased when compared with those before treatment,differences being significant(P < 0.05).All symptoms scores in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment of 12 months,carotid IMT in the observation group was decreased when compared with that before treatment,the difference being significant(P<0.05).The comparison of carotid IMT between the two groups showed significance in differences(P<0.05).There was no serious adverse reaction in both groups.Conclusion:The therapy of Xuefu Zhuyu capsules combined with western medicine for senile hypertension with heart blood stasis type can effectively improve clinical symptoms and clinical effect as well as decrease carotid IMT,which has great significance in reducing the occurrence of cardiovascular and cerebrovascular events.

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陈武忠.血府逐瘀胶囊联合西药治疗老年高血压临床研究[J].新中医,2018,50(4):56-58

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  • 在线发布日期: 2018-04-10
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