Objective：To observe the clinical effect of Huazhuo Xiaoban tang combined with western medicine for carotid plaques.Methods：Divided 110 cases of patients with carotid atherosclerosis with phlegm-turbidity stasis syndrome into the control group and the treatment group randomly.Both groups were given pravastatin sodium tablets and aspirin enteric-coated tablets for treatment，while the treatment group was additionally given Huazhuo Xiaoban tang.The treatment of both groups lasted for four months.Detected carotid intima-media thickness(IMT)by means of color doppler ultrasound，recorded the number of plaques，and evaluated degree of plaque hardening by using plaque integration method.Detected high-density lipoprotein cholesterol(HDL-C)， low-density lipoprotein cholesterol(LDL-C)， triglycerides(TG)， total cholesterol(TC)，high-sensitivity C-reactive protein(hs-CRP)， fibrinogen(FIB)， and levels of d-dimer(D-D)before and after treatment.Results：After treatment，IMT of carotid became thinner and the number of plaques was decreased in both groups.Scores of Crouse，levels of TG，TC，LDL-C，and hs-CRP，and scores of Chinese medicine syndromes were all decreased，while the levels of HDL-C were increased when comparing with those before treatment，differences being significant(P ＜ 0.01).IMT in the treatment group was lower than that in the control group(P＜0.05)and the number of plaques in the treatment group was lower than that in the control group(P＜0.05).Scores of Crouse，scores of Chinese medicine syndrome and levels of TG，TC，LDL-C as well as hs-CRP in the treatment group were all lower than those in the control group(P ＜ 0.05)，while the level of HDL-C was higher than that in the control group(P＜0.05).Conclusion：The therapy of Huazhuo Xiaoban tang combined with western medicine can help reducing the number and thickness of carotid plaques，alleviate clinical symptoms，and regulating lipid metabolism，anti-inflammatory and improving blood viscosity，which will help reducing the risk factors for adverse cardiovascular and cerebrovascular diseases.