补益强心片治疗慢性心力衰竭Meta分析
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R541.6

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国家自然科学基金项目(81673891)


Meta-analysis of Buyi Qiangxin Tablets for Chronic Heart Failure
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    摘要:

    目的:评价补益强心片治疗慢性心力衰竭的临床疗效以及安全性。方法:计算机搜索数据库知网、万方、维普、PubMed、EMbase、The Cochrane Library,搜索以补益强心片和基础西药治疗慢性心力衰竭,以心功能Ⅱ、Ⅲ级患者的有关随机对照试验研究文献,检索时限为从建库开始到2017年1月为止,语种为中文和英文;根据纳入标准与排除标准,由2位研究者分别进行文献选取、提取资料,质量评价,采用RevMan 5.3软件进行Meta分析。结果:最终纳入7项随机对照研究文献,共计患者483例。心衰疗效:补益强心片优于对照组疗效[OR=4.54,95%CI(2.33,9.26),P<0.01];心室射血分数 (LVEF):[MD=3.88,95%CI(3.18,4.59),P < 0.01];生活质量: [MD=-11.23,95%CI(-14.45,-8.01),P < 0.01];心功能疗效: [OR=4.44,95%CI(1.63,11.93),P <0.01];N末端脑钠肽(NT-proBNP):[SMD=-1.58,95%CI(-1.88,-1.282),P <0.01]。结论:补益强心片疗效满意,能改善慢性心衰患者的心衰疗效、心室射血分数、心功能疗效。但受纳入研究文献质量和患者样本量少等因素制约,上述结论尚需开展更多高质量研究加以验证。

    Abstract:

    Objective: To evaluate the clinical effect of Buyi Qiangxin tablets for chronic heart failure and its safety.Methods: Searched the database including CNKI,Wanfang,VIP, PubMed, EMbase and The Cochrane Library for the relevant research literature of randomized controlled trials on Buyi Qiangxin tablets combined with basic western medicine for chronic heart failure and on patients with cardiac function II and III from establishment to January 2016 Meta-analysis in the language of English and Chinese by computer; according to inclusive criteria and exclusive criteria, two researchers separately screened the literature,extracted data and evaluated the quality, and the meta-analysis was conducted via RevMan 5.3 software.Results:Finally included 7 categories of randomized controlled research literature, 483 cases of patients in total.The clinical effect:the one with Buyi Qiangxin tablets was better than that in the control group[OR=4.54,95%CII(2.33,9.26),P < 0.01];left ventricular ejection fraction(LVEF):[MD=3.88,95%CI(3.18,4.59),P < 0.01];life quality: [MD=-11.23, 95%CI(-14.45, -8.01), P < 0.01]; the clinical effect of cardiac function: [OR=4.44, 95%CI(1.63,11.93),P < 0.01],NT-proBNP:[SMD=-1.58,95%CI(-1.88,-1.282),P < 0.01].Conclusion:Buyi Qiangxin tablets has satisfactory clinical effect,and can improve the clinical effect of heart failure,ventricular ejection fraction and the clinical effect of cardiac function in patients with chronic heart failure.But limited by factors including the quality of literature in the research,lack of patients and so on,the conclusion mentioned above still needs more researches of high quality to be justified.

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李济廷,卢洁,刘琛怡,庞延,卢健棋.补益强心片治疗慢性心力衰竭Meta分析[J].新中医,2018,50(4):27-31

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  • 在线发布日期: 2018-04-10
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