Objective：To observe the clinical curative effect of Guben Xiaoshi prescription in treating Osteonecrosis of the femoral head of phlegm-stasis blocking collateral type.MethodsSelected 100 cases of patients with osteonecrosis of the femoral head of phlegm-stasis blocking collateral type who were admitted into the department of orthopaedics in our hospital，and divided them into two groups randomly，50 cases in each group.The control group receivedthe treatment of iclofenac sodium combined with Xianling Gubao capsules，while the observation group received the treatment of Guben Xiaoshi prescription.Observed Harris scores，visual analog scale(VAS)scores，bone mineral density，alkaline phosphatase(ALP)，bone gla protein(BGP)，and bone morphogenetic protein(BMP-2)as well as imageology indexes before and after treatment，and evaluated the overall clinical curative effect.ResultsAfter treatment， Harris scores in both groups were obviously increased，while VAS scores in both groups were evidently decreased.The density of femur and cervical vertebra were increased.The levels of BGP and BMP-2 were clearly increased，while the ALP levels were distinctly declined.The improvements of patients in the observation group were better than those in the control group.All differences were significant(P＜0.05).The total effective rate was 96.0%in the observation group and was 76.0%in the control group，the difference being significant(P＜0.05).ConclusionThe application of Guben Xiaoshi prescription for osteonecrosis of the femoral head of phlegm-stasis blocking collateral type can improve hip joint function of patients， release pain， and improve biochemical indexes of osteonecrosis of the femoral head and the clinical effect.