| 摘要: |
| 目的：观察仙脂封髓汤治疗类风湿性关节炎患者的临床疗效及其对外周血护骨素（OPG）表达水平的影响。方法：将符合研究标准的类风湿性关节炎患者60例随机分成治疗组32例，对照组30例。对照组给予非甾体类抗炎药、甲氨蝶呤、钙尔奇D片治疗；治疗组在对照组治疗方案的基础上加仙脂封髓汤口服。结果：治疗后，2组晨僵、握力、疼痛关节个数、关节休息痛评分、血沉（ESR）、C-反应蛋白（CRP）、类风湿因子（RF）、骨密度（BMD）、OPG分别与治疗前比较，差异均有统计学意义（P＜0.05）；治疗后，2组间晨僵、握力、疼痛关节个数、ESR、RF、BMD、OPG情况比较，差异均有统计学意义（P＜0.05）。提示治疗组在改善晨僵、握力、关节疼痛方面优于对照组，在改善OPG表达水平及BMD方面优于对照组。2组患者有2例出现不良反应，主要有恶心呕吐、皮疹、消化不良、腹泻。2组不良反应均较轻，均能耐受完成临床观察。结论：仙脂封髓汤能改善类风湿性关节炎患者临床症状，提高护骨素表达水平，增加骨密度。 |
| 关键词: 类风湿性关节炎 仙脂封髓汤 护骨素 骨密度 类风湿因子 |
| DOI： |
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| Curative Effect of Xianzhi Fengsui Tang for Rheumatoid Arthritis and Its Influence on the Expression Levels of Osteoprotegerin in Peripheral Blood |
| ZHENG Xianmin,YE Renqun,WANG Hui,ZHANG Yue,YAN Yanjun,XU Zejun |
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| Abstract: |
| Objective：To observe the curative effect of Xianzhi Fengsui tang for rheumatoid arthritis and the expression levels of osteoprotegerin(OPG)in peripheral blood.Methods：Divided 60 cases of patients with rheumatoid arthritis according with the criteria of study into the treatment group and the control group randomly，30 cases in each group.Both groups
receivednon-steroidal anti-inflammatory drugs，methotrexate and Caltrate-D tablets，while the treatment group additionally received Xianzhi Fengsui tang orally.Results：After treatment，morning stiffness，grip strength，the number of painful joints，scores of articular rest pain，erythrocyte sedimentation rata(ESR)，C-reactive protein(CRP)，rheumatoid factor(RF)，bone mineral density(BMD)，and osteoprotegerin(OPG)were respectively compared between the two groups before and after treatment，differences being significant(P ＜ 0.05).After treatment，morning stiffness，grip strength，the number of painful joints，ESR，RF，BMD，OPG in both groups were compared，differences being significant(P ＜ 0.05).The results suggested that the treatment group was better than the control group in improving morning stiffness，grip strength and limbs activity with painful joints，and it was superior to the control group in expression levels of OPG and BMD.There were two cases of adverse reaction being found in both groups，mainly including nausea and vomiting，rash，dyspepsia，and diarrhea.Cases of adverse reaction in both groups were all mild and tolerable for completing the clinical observation.Conclusion：Xianzhi Fengsui tang can improve clinical symptoms of patients with rheumatoid arthritis，enhance expression levels of osteoprotegerin and increase bone mineral density. |
| Key words: Rheumatoid arthritis Xianzhi Fengsui tang Osteoprotegerin(OPG) Bone mineral density(BMD) Rheumatoid factor(RF) |
