健胃消胀片治疗非酒精性脂肪性肝病临床研究
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R575.5

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广东省中医药局建设中医药强省立项不资助科研课题(20142148);广东省中医药局首批名中医师承项目(粤财社[2014]539);“十一五”国家中医药管理局重点专科评审验收合格项目(国中医药医政函[2012]86号)


Clinical Study of Jianwei Xiaozhang Tablets for Nonalcoholic Fatty Liver Disease
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    摘要:

    目的:观察健胃消胀片治疗非酒精性脂肪性肝病(NAFLD)的临床效果。方法:纳入60例NAFLD患者,随机分为治疗组和对照组各30例,治疗组服用健胃消胀片治疗,对照组服用易善复胶囊治疗,2组患者均治疗12周,观察2组患者的临床主要症状积分、肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)]、血脂指标[甘油三酯(TG)、总胆固醇(TC)]及肝脏超声等的变化。结果:治疗后,治疗组总有效率为90.00%,对照组总有效率为83.33%。2组疗效比较,差异无统计学意义(P>0.05)。2组ALT、AST水平均较治疗前下降(P<0.05),治疗组2项指标水平均低于对照组(P<0.05)。2组TC、TG水平与主症积分、肝脏超声积分均较治疗前下降(P<0.05),2组TC、TG、肝脏超声积分比较,差异均无统计学意义(P>0.05),治疗组主症积分低于对照组(P<0.05)。结论:健胃消胀片治疗NAFLD在临床疗效及改善血脂代谢方面与易善复胶囊相当,而在改善临床症状及肝功能等方面有明确优势。

    Abstract:

    Objective: To observe the clinical effect of Jianwei Xiaozhang tablets for nonalcoholic fatty liver disease(NAFLD).Methods:Divided 60 cases of patients with NAFLD into the treatment group and the control group randomly,30 cases in each group.The treatment group was given Jianwei Xiaozhang tablets,while the control group was given essentiale capsules.Both groups receivedtreatment for 12 weeks.Observed the changes of main clinical symptom scores,liver function indexes which includes alanine transaminase(ALT),aspartate aminotransferase(AST),and serum lipids indexes which includes triglyceride(TG),total cholesterol(TC),as well as liver ultrasound.Results:After treatment,the total effective rate was 90.00%in the treatment group and was 83.33%in the control group,there being no significant difference(P>0.05).Levels of ALT and AST of both groups were declined when compared with those before treatment(P<0.05),while levels of the two indexes in the treatment group were lower than those in the control group(P<0.05).Levels of TC,TG and scores of main clinical symptom,liver ultrasound were declined when compared with those before treatment(P<0.05).No significance was found in the comparison of levels of TC,TG and scores of liver ultrasound of both groups(P>0.05),while scores of main clinical symptom of the treatment group were lower than those of the control group(P<0.05).Conclusion:In terms of curativeeffect and improvement of blood lipid metabolism,Jianwei Xiaozhang tablets are well-matched in treating NAFLD when compared with essentiale capsules,while it has clear advantages in improving clinical symptoms and liver function.

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卢晓敏,袁瑞兴,王家华,房志科,董明国.健胃消胀片治疗非酒精性脂肪性肝病临床研究[J].新中医,2017,49(12):41-43

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  • 在线发布日期: 2017-12-02
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