小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎临床研究
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R725.6

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Clinical Study of Xiao'er Chiqiao Qingre Granules Combined with Ribavirin for Herpangina in Children
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    摘要:

    目的:观察小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎的临床疗效。方法:选取 82 例疱疹性咽峡炎患儿,按随机数字表法分为试验组及常规组,每组 41 例。常规组给予利巴韦林治疗,试验组给予小儿豉翘清热颗粒联合利巴韦林 治疗,2 组均治疗 3 d。比较 2 组临床疗效及不良反应发生率,观察 2 组治疗前后血清白细胞介素-6(IL-6)、降钙素原(PCT)、C-反应蛋白(CRP)水平及血清免疫球蛋白(Ig)A、IgG、IgM 水平的变化。结果:试验组总有效率为 97.56%,常规组总有效率为 82.93%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组血清 IL-6、PCT 及 CRP 水平均较治疗前降低(P<0.05),试验组血清 IL-6、PCT 及 CRP 水平均低于常规组(P<0.05)。治疗后,2 组 IgA、IgG 水平均较治疗前升高,试验组 IgA、IgG 水平均高于常规组 (P<0.05);2 组 IgM 水平均较治疗前降低 (P<0.05),试验组 IgM 水平低于常规组 (P<0.05)。试验组不良反应发生率为 4.88%,常规组不良反应发生率为 9.76%,2 组比较,差异无统计学意义 (P>0.05)。结论:小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎,可以减轻炎症反应,提高患儿的免疫功能,相较于单一利巴韦林治疗效果更好。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Xiao'er Chiqiao Qingre granules combined with ribavirin for herpangina in children. Methods: A total of 82 cases of children with herpangina were selected and divided into the experiment group and the routine treatment group according to the random number table method,41 cases in each group. The routine treatment group was treated with ribavirin,and the experiment group was treated with Xiao'er Chiqiao Qingre granules combined with ribavirin. Both groups were treated for three days. The clinical effect and the incidence of adverse reactions were compared between the two groups. Before and after treatment,the changes in the levels of interleukin-6 (IL-6),procalitonin(PCT),C-reactive protein(CRP),immunoglobulin(Ig) A,IgG,and IgM in serum in the two groups were observed. Results: The total effective rate was 97.56% in the experiment group, and 82.92% in the routine treatment group,the difference being significant(P<0.05). After treatment,the levels of IL- 6,PCT and CRP in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the three levels above in the experiment group were lower than those in the routine treatment group(P<0.05). After treatment,the levels of IgA and IgG in the two groups were increased, when compared with those before treatment(P<0.05), and the levels of IgA and IgG in the experiment group were higher than those in the routine treatment group(P<0.05);the levels of IgM in the two groups were decreased when compared with those before treatment(P<0.05),and the level of IgM in the experiment group was lower than that in the routin treatment group(P<0.05). The incidence of adverse reactions was 4.88% in the experiment group,and 9.76% in the routine treatment group,there being no significance in the difference(P>0.05). Conclusion: The therapy of Xiao'er Chiqiao Qingre granules combined with ribavirin in the treatment of herpangina in children can relieve inflammatory responses,and improve the immune function,whose curative effect is better than that of simple ribavirin.

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吴方春,张飞飞,吴海洁.小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎临床研究[J].新中医,2021,53(1):94-97

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  • 在线发布日期: 2021-01-11
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