参地颗粒联合黄葵胶囊治疗慢性肾小球肾炎临床研究及对血清炎症因子、PCX及B7-1的影响
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Clinical Study on Shendi Granules Combined with Huangkui Capsules for Chronic Glomerulonephritis and Its Effect on Serum Inflammatory Factors,PCX and B7-1
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    摘要:

    目的:观察参地颗粒联合黄葵胶囊治疗慢性肾小球肾炎的临床疗效及对患者血清炎症因子水平、尿足萼糖蛋白(PCX)、B7-1 水平的影响。方法:将慢性肾小球肾炎患者 70 例随机分为观察组与对照组各 35 例,2 组均给予规范化西医治疗,在此基础上,对照组加用黄葵胶囊治疗,观察组加用参地颗粒联合黄葵胶囊治疗。比较 2 组临床疗效、24 h 尿蛋白定量(24 hUTP)、血清炎症因子水平及尿 PCX 和 B7-1 水平。结果:2 组用药疗效观察组显著高于对照组 (P<0.05)。2 组治疗后24 hUTP、血清 IL-2、IL-17 水平较治疗前降低 (P<0.05),IL-4 水平较前升高 (P<0.05),且 2 组组间比较,差异有统计学意义(P<0.05)。与治疗前比较,2 组治疗后尿 PCX、B7-1 水平均降低(P<0.05),组间治疗后比较,差异有统计学意义(P<0.05)。结论:参地颗粒联合黄葵胶囊治疗慢性肾小球肾炎疗效确切,可显著提高临床疗效,改善患者肾功能,调节炎症因子水平和PCX、B7-1 水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Shendi granules combined with Huangkui capsules for chronic glomerulonephritis and its effect on the levels of serum inflammatory factors,urinary podocalyxin(PCX) and B7-1. Methods: A total of 70 cases of patients with chronic glomerulonephritis were randomly divided into the observation group and the control group,35 cases in each group. Both groups were given standardized western medicine treatment;the control group was additionally treated with Huangkui capsules,and the observation group was additionally treated with Shendi granules combined with Huangkui capsules. The clinical effect,24 h urine protein excretion(24 hUTP) as well as the levels of serum inflammatory factors,urinary PCX and B7-1 in the two groups were compared. Results:The curative effect of medication in the observation group was significantly higher than that in the control group(P<0.05). After treatment,the levels of 24 hUTP and IL-2 and IL-17 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL- 4 were increased(P<0.05), and the comparison between the two groups showed significance in the difference(P<0.05). After treatment,the levels of urinary PCX and B7-1 in the two groups were decreased when compared with those before treatment(P<0.05),and the comparison between the two groups showed significance in the difference(P< 0.05). Conclusion:The therapy of Shendi granules combined with Huangkui capsules has definite curative effect in treating chronic glomerulonephritis,which can significantly enhance the clinical effect,improve the kidney function,and regulate the levels of inflammatory factors,PCX and B7-1.

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程孝雨.参地颗粒联合黄葵胶囊治疗慢性肾小球肾炎临床研究及对血清炎症因子、PCX及B7-1的影响[J].新中医,2021,53(1):61-64

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  • 在线发布日期: 2021-01-11
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