安宫牛黄丸联合西药治疗脑出血临床研究
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R743.34

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Clinical Study on Angong Niuhuang Pills Combined with Western Medicine for Cerebral Hemorrhage
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    摘要:

    目的:观察对脑出血患者术后给予安宫牛黄丸联合西药治疗的疗效。方法:选取 200 例脑出血患者为研究对象,以随机数字表法分为 2 组 (各 100 例)。2 组入院后均行脑外科手术治疗,对照组术后给予常规西药治疗,观察组术后在对照组基础上给予安宫牛黄丸治疗。比较 2 组治疗后临床疗效、中医证候积分、美国国立卫生研究院卒中量表 (NIHSS) 评分、改良Barthel 指数 (MBI) 评分及氧化应激指标。结果:治疗后观察组总有效率 (92.00%) 优于对照组 (65.00%)(P<0.05)。治疗后,2 组中医证候积分、NIHSS 评分均较治疗前降低(P<0.05),观察组中医证候积分、NIHSS 评分均低于对照组 (P<0.05);2 组 MBI 评分均较治疗前升高(P<0.05),观察组 MBI 评分高于对照组(P<0.05)。治疗后,2 组血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(TAC)水平均较治疗前升高(P<0.05),血清丙二醛(MDA)水平均较治疗前降低 (P<0.05);观察组血清 SOD、GSH-Px、TAC 水平均高于对照组 (P<0.05),血清 MDA 水平低于对照组 (P<0.05)。结 论:在脑出血术后给予安宫牛黄丸联合西药治疗疗效满意,可有效缓解症状,减轻神经功能损伤,提高日常生活自理能力,具有明显的抗氧化应激作用。

    Abstract:

    Abstract:Objective:To observe the therapeutic effect of Angong Niuhuang Pills combined with western medicine on patients with cerebral hemorrhage after operation. Methods:200 cases of cerebral hemorrhage patients were selected as the research objects,and they were divided into 2 groups (100 cases each) by random number table method. Both groups were treated with brain surgery after admission, the control group was treated with conventional western medicine after operation, and the observation group was treated with Angong Niuhuang pills on the basis of the control group after operation. The clinical efficacy, the scores of Traditional Chinese Medicine(TCM) syndrome and National Institute of the Health Stroke Scale(NIHSS) after treatment were compared between the two groups,as well as Modified Barthel Index(MBI) score and oxidative stress index. Results:After treatment,the total clinical effective rate of the observation group(92.00%) was better than that of the control group(65.00%) (P<0.05);after treatment,the scores of TCM syndromes and NIHSS in the two groups were lower than those before treatment(P<0.05). The scores of TCM syndromes and NIHSS of the observation group were lower than those of the control group(P<0.05);the MBI scores of the two groups were higher than those before treatment(P<0.05),and the MBI scores in the observation group were higher than those in the control group(P< 0.05). After treatment, the levels of serum superoxide dismutase(SOD), glutathione peroxidase(GSH- Px), and total antioxidant capacity(TAC) in the two groups were higher than those before treatment(P<0.05). The level of malondialdehyde (MDA) was lower than that before treatment(P<0.05);the serum SOD,GSH-Px and TAC levels of the observation group were higher than those in the control group(P<0.05),and the serum MDA level was lower than that in the control group(P< 0.05). Conclusion: After intracerebral hemorrhage, Angong Niuhuang Pills combined with western medicine has a satisfactory therapeutic effect,which can effectively relieve symptoms,reduce nerve damage,improve daily life self-care ability,and have obvious anti-oxidative stress effects.

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吕本洋.安宫牛黄丸联合西药治疗脑出血临床研究[J].新中医,2021,53(1):53-56

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  • 在线发布日期: 2021-01-11
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