平颤汤联合盐酸美金刚片治疗肝肾不足型帕金森病临床研究
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R742.5

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河南省教育厅科研基金项目(162102310454)


Clinical Study on Pingchan Tang Combined with Memantine Hydrochloride Tablets for Parkinson Disease of Liver-Kidney Deficiency Type
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    摘要:

    目的:观察平颤汤联合盐酸美金刚片治疗肝肾不足型帕金森病的临床疗效。方法:选取肝肾不足型帕金森病患者120 例,按随机数字表法分为对照组和观察组各60 例。2 组患者入院后根据病情均予以常规对症治疗,对照组予盐酸美金刚片治疗,观察组在对照组基础上加用平颤汤治疗。比较2 组治疗前后认知功能、运动功能以及血清中炎症因子指标、血清α-突触核蛋白(α-SYN)、过氧化脂质(LPO) 和丙二醛(MDA) 含量的差异,统计分析临床疗效以及不良反应发生情况。结果:观察组总有效率为86.67%,高于对照组71.67%,差异有统计学意义(P<0.05)。治疗后,2 组简易智力状态检查量表(MMSE) 评分较治疗前升高,且观察组MMSE 评分高于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组统一帕金森病评定量表第Ⅱ部分(UPDRSⅡ)、第Ⅲ部分(UPDRSⅢ) 评分较治疗前下降,且观察组UPDRSⅡ、UPDRSⅢ评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组血清肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、α-SYN、LPO 及MDA 水平较治疗前降低(P<0.05),且观察组血清TNF-α、IL-6、IL-8、α-SYN、LPO 及MDA 水平低于对照组(P<0.05)。结论:平颤汤联合盐酸美金刚片治疗肝肾不足型帕金森病能够降低患者全身炎症反应,改善全身应激状态,利于认知功能恢复,且安全性较好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Pingchan tang combined with memantine hydrochloride tablets for Parkinson disease of liver-kidney deficiency type. Methods:A total of 120 cases of patients with Parkinson disease of liverkidney deficiency were selected and divided into the control group and the observation group according to the random number table method, 60 cases in each group. Both groups were given routine symptomatic treatment based on condition after admission. The control group was given memantine hydrochloride tablets,and the observation group was additionally given Pingchan tang based on the treatment of the control group. Cognitive function, motor function, and the differences of inflammatory factors indexes, α- synuclein(α- SYN) and the contents of lipid peroxide(LPO) and malondialdehyde(MDA) in serum before and after treatment were compared between the two groups. The clinical effect and the incidence of adverse reactions were counted and analyzed. Results: The total effective rate was 86.67% in the observation group, higher than that of 71.67% in the control group,the difference being significant(P<0.05). After treatment,the scores of Mini- Mental State Examination(MMSE) in the two groups were increased when compared with those before treatment,and the score in the observation group was higher than that in the control group,differences being significant(P<0.05). After treatment,the scores of Unified Parkinson Disease Rating Scale Ⅱ(UPDRSⅡ) and Ⅲ(UPDRSⅢ) in the two groups were decreased when compared with those before treatment,and the scores of UPDRSⅡand UPDRSⅢ in the observation group were lower than those in the control group, differences being significant(P<0.05). After treatment, the levels of tumor necrosis factor- α (TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),α-synuclein,LPO and MDA in serum were decreased when compared with those before treatment,and the six levels in serum in the observation group were lower than those in the control group (P<0.05). Conclusion:The application of Pingchan tang combined with memantine hydrochloride tablets in treating patients with Parkinson disease of liver-kidney deficiency type,can reduce their systemic inflammatory response,improve systemic stress state,and conduce to the recovery of cognitive function,with better safety.

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靳明伟,徐华明.平颤汤联合盐酸美金刚片治疗肝肾不足型帕金森病临床研究[J].新中医,2020,52(16):69-73

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  • 在线发布日期: 2020-08-19
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