Abstract：Objective：To observe the clinical effect of Kangxian Yixin prescription for patients with dilated cardiomyopathy (DCM) of qi deficiency and blood stasis type complicated with the heart failure， and to analyse its effect on myocardial function and the level of neuroendocrine factors. Methods：A total of 112 cases of DCM patients of qi deficiency and blood stasis type complicated with the heart failure were divided into two groups according to the random number table method，56 cases in each group. The control group was given comprehensive treatment of western medicine，and the observation group was additionally given Kangxian Yixin prescription based on the treatment of the control group. Both groups were continuously treated for six months. The levels of aldosterone(ALD)，N- terminal pro- B- type natriuretic peptidec(NT- proBNP)，plasma renin activity(PRA)，angiotensinⅡ(AngⅡ)，endothelin- 1(ET- 1)，and thromboxane B2 in the plasma(TXB2) before and after treatment were compared between the two groups. Left ventricular internal dimension diastole(LVEDd)， left ventricular ejection fraction(LVEF)，left ventricular end systolic volume(LVESV)，left ventricular end diastolic volume(LVEDV)，6-minute walking distance(6- MWT)， Chinese medicine syndrome scores， and adverse events before and after treatment were compared between the two groups. The clinical effect of integrated Chinese and western medicine was evaluated. Results： The total clinical effective rate of Chinese medicine and western medicine in the observation group were higher than those in the control group，differences being significant(P＜0.05). After treatment，the myocardial function indexes such as LVEF and 6- MWT in the observation group were higher than those in the control group， and LVEDd， LVESV and LVEDV lower， differences being significant(P＜0.05)；the levels of neuroendocrine factors including NT-proBNP，ALD，PRA，ET-1，AngⅡ and TXB2 in the observation group were lower than those in the control group， differences being significant(P＜0.05)； Chinese medicine syndrome scores in the observation group were lower than those in the control group，differences being significant(P＜0.05)； there was no significant difference being found in the comparison of the incidence of adverse events between the two groups(P＞0.05). Conclusion： Kangxian Yixin prescription has significant curative effect of integrated Chinese and western medicine in treating DCM patients of qi deficiency and blood stasis type complicated with the heart failure，which can reduce the expression of neuroendocrine factors，and improve myocardial function，with high safety.