目血康胶囊联合羟苯磺酸钙胶囊治疗糖尿病视网膜病变临床研究
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R587.2

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Clinical Study on Muxuekang Capsules Combined with Calcium Dobesilate Capsules for Diabetic Retinopathy
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    摘要:

    目的:探讨目血康胶囊联合羟苯磺酸钙胶囊对糖尿病视网膜病变患者血清瘦素(Leptin)、血管内皮生长因子(VEGF)、孤儿G 蛋白偶联受体APJ 的天然配体(Apelin) 水平的影响。方法:选取糖尿病视网膜病变患者104 例,按随机数字表法分为研究组和对照组各52 例。对照组给予羟苯磺酸钙胶囊治疗,研究组在对照组基础上联合目血康胶囊治疗,观察2 组平均视力、Leptin、VEGF、Apelin 水平以及眼动脉舒张末期血流速度(Edv)、收缩期峰值血流速度(Psv)、阻力指数(RI)、搏动指数(PI) 变化。结果:治疗后,2 组视力均得到提升,研究组高于对照组(P<0.05);2 组血清中Leptin、VEGF、Apelin 含量及眼部RI、PI 指标均降低,且研究组低于对照组(P<0.05);2 组Edv、Psv 升高,且研究组高于对照组(P<0.05)。结论:目血康胶囊联合羟苯磺酸钙可有效改善糖尿病视网膜病变患者眼部视力状态,降低血液中Leptin、VEGF、Apelin 因子含量,提升眼动脉血流动力学水平。

    Abstract:

    Abstract:Objective:To discuss the effect of Muxuekang capsules combined with calcium dobesilate capsules on levels of serum leptin(Leptin),vascular endothelial growth factor(VEGF) and natural ligand of the orphan G-protein coupled receptor APJ(Apelin) in patients with diabetic retinopathy. Methods: A total of 104 cases of patients with diabetic retinopathy were divided into the study group and the control group according to the random number table method,52 cases in each group. The control group was treated with calcium dobesilate capsules, and the study group was additionally treated with Muxuekang capsules based on the treatment of the control group. The changes in average visual acuity, levels of Leptin, VEGF and Apelin,as well as end-diastolic velocity(Edv),peak systolic velocity(Psv),resistance index(RI) and pulsatility index (PI) in ophthalmic artery in the two groups were observed. Results:After treatment,the visual acuity in the two groups was improved,and the one in the study group was higher than that in the control group(P<0.05);the contents of Leptin,VEGF and Apelin in serum as well as RI and PI in the eyes in the two groups were decreased,and the indexes in the study group were lower than those in the control group(P<0.05);Edv and Psv in the two groups were increased,and the ones in the study group were higher than those in the control group(P<0.05). Conclusion:Muxuekang capsules combined with calcium dobesilate capsules can effectively improve the visual acuity in patients with diabetic retinopathy, reduce the contents of Leptin,VEGF and Apelin in the blood,and improve the levels of hemodynamics in ophthalmic artery.

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夏冰.目血康胶囊联合羟苯磺酸钙胶囊治疗糖尿病视网膜病变临床研究[J].新中医,2020,52(21):31-34

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  • 在线发布日期: 2020-11-05
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