补肾益气化瘀方治疗老年骨质疏松症疗效观察及对骨代谢标志物的影响
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Clinical Observation of Bushen Yiqi Huayu Prescription for Senile Osteoporosis and Its Effect on Bone Metabolic Markers
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    摘要:

    目的:观察补肾益气化瘀方治疗老年骨质疏松症(OP) 的临床疗效及其对骨代谢的影响。方法:将OP 老年患者88 例随机分为对照组与联合组,各44 例。对照组给予阿法骨化醇治疗,联合组在对照组的基础上联合补肾益气化瘀方治疗。观察比较2 组中医证候积分、骨密度值、骨代谢血清标志物[骨碱性磷酸酶(BALP)、降钙素(CT)、抗酒石酸盐酸性磷酸酶异构体5b(TRACP-5b)] 水平及临床总体疗效。结果:总有效率联合组为95.45%,对照组为65.91%,2 组比较,差异有统计学意义(P<0.05)。2 组腰背疼痛、腰膝酸软、神疲肢倦等中医证候积分均较治疗前降低(P<0.05);且联合组各项积分均低于对照组(P<0.05)。治疗后,2 组患者L2~4、髋部骨密度均较治疗前升高(P<0.05),且联合组L2~4、髋部骨密度均高于对照组(P<0.05)。治疗后,2 组患者BALP、TRACP-5b 水平均较治疗前降低(P<0.05),CT 水平较治疗前升高(P<0.05),且联合组各项骨代谢指标改善较对照组更显著(P<0.05)。结论:补肾益气化瘀方联合阿法骨化醇治疗OP,可有效缓解患者临床症状,增加骨密度,促进骨代谢,从而更好地保护老年患者的骨与关节系统。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Bushen Yiqi Huayu prescription for senile osteoporosis(OP) and its effect on bone metabolism. Methods:A total of 88 cases of senile OP patients were randomly divided into the control group and the combination group,44 cases in each group. The control group was treated with alfacalcidol,and the combination group was additionally treated with Bushen Yiqi Huayu prescription based on the treatment of the control group. Chinese medicine syndrome scores, bone density values, levels of serum markers of bone metabolism including bone alkaline phosphatase(BALP), calcitonin(CT) and tartrate- resistant acid phosphatase isomer 5b(TRACP- 5b), and the total clinical effect in the two groups were observed and compared. Results: The total effective rate was 95.45% in the combination group and 65.91% in the control group,the difference being significant(P<0.05). The scores of Chinese medicine syndromes including low back pain, soreness in the waist and knees, and mental and physical lassitude in the two groupswere all decreased when compared with those before treatment(P<0.05); the scores in the combination group were significantly lower than those in the control group(P<0.05). After treatment,the bone mineral density of lumbar L2~4 and hip in the two groups was significantly increased when compared with that before treatment(P<0.05), and the index in the combination group was higher than that in the control group(P<0.05). After treatment, the levels of BALP and TRACP- 5b in the two groups were decreased when compared with those before treatment(P<0.05), and the CT level was increased(P<0.05); the improvement of bone metabolic markers in the combination group was more significant than that in the control group(P< 0.05). Conclusion: The therapy of Bushen Yiqi Huayu prescription combined with alfacalcidol for OP can effectively relieve symptoms, increase bone mineral density, and promote bone metabolism, so as to better protect the bone and joint system of senile patients.

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孙奇华,何爱玉,祝炳军,程桂兰,俞建标.补肾益气化瘀方治疗老年骨质疏松症疗效观察及对骨代谢标志物的影响[J].新中医,2020,52(20):81-84

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  • 在线发布日期: 2020-10-19
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