解郁化痰汤治疗脑梗死后抑郁临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R74

基金项目:


Clinical Study on Jieyu Huatan Tang for Depression After Cerebral Infarction
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察解郁化痰汤治疗脑梗死后抑郁患者临床疗效及对血清脑源性神经营养因子(BDNF)、P 物质(SP) 和5-羟色胺(5-HT) 水平的影响。方法:选取86 例脑梗死后抑郁患者,按随机数字表法分为对照组和观察组各43 例。对照组给予富马酸喹硫平片治疗,观察组在对照组基础上加用解郁化痰汤治疗。比较2 组临床疗效,观察治疗前后汉密尔顿抑郁量表(HAMD) 评分、匹茨堡睡眠质量指数量表(PSQI) 评分、脑卒中康复运动功能评定表(STREAM) 评分、美国国立卫生研究院卒中量表(NIHSS) 评分变化情况,检测血清BDNF、SP 和5-HY 水平。结果:观察组总有效率为93.02%,高于对照组72.09%,差异有统计学意义(P<0.05)。治疗前,2 组HAMD 评分、PSQI 评分、STREAM 评分及NIHSS 评分比较,差异无统计学意义(P>0.05)。治疗后,2 组HAMD 评分、PSQI 评分及NIHSS 评分较治疗前降低,STREAM 评分较治疗前升高(P<0.05);观察组治疗后HAMD 评分、PSQI 评分及NIHSS 评分低于对照组,STREAM 评分高于对照组(P<0.05)。治疗前,2 组血清BDNF、SP、5-HY 水平比较,差异无统计学意义(P>0.05)。观察组治疗后血清BDNF、5-HY 水平较治疗前升高,而SP 水平较治疗前降低(P<0.05);观察组治疗后血清BDNF、5-HY 水平高于对照组,而SP 水平低于对照组(P<0.05)。结论:解郁化痰汤治疗脑梗死后抑郁临床疗效较好,可缓解患者抑郁情绪及改善睡眠质量,改善患者运动功能及神经功能,提高血清BDNF 和5-HY 水平,降低SP 水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Jieyu Huatang tang in the treatment of depression after cerebral infarction and its effect on the changes of brain-derived neurotrophic factor(BDNF) , Substance P(SP) and 5-hydroxytryptamine(5-HT) in serum. Methods:A total of 86 patients with depression after cerebral infarction were selected and divided into the control group and the observation group according to random number table,43 cases in each group. The control group was treated with quetiapine fumarate tablets and the observation group was additionally treated with Jieyu Huatang tang based on the treatment of the control group. The clinical effect in the two groups was compared, and the changes in the scores of Hamilton Depression Scale(HAMD), Pittsburgh Sleep Quality Index(PSQI), Stroke Rehabilitation Assessment of Movement(STREAM) and National Institutes of Health Stroke Scale(NIHSS) before and after treatment were observed;the levels of BDNF,SP and 5-HY in serum were detected. Results:The total effective rate was 93.02% in the observation group, higher than that of 72.09% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference in the comparison of the scores of HAMD, PSQI, STREAM and NIHSS between the two groups(P>0.05). After treatment, the scores of HAMD, PSQI and NIHSS in the two groups were decreased when compared with those before treatment,and the STREAM score was increased when compared with that before treatment(P<0.05);the scores of HAMD,PSQI and NIHSS in the observation group were lower than those in the control group and the STREAM score was higher(P<0.05). Before treatment, there was no significant difference in the comparison of the levels of BDNF,SP and 5-HY in serum between the two groups(P>0.05). After treatment,the levels of BDNF and 5-HY in serum were increased when compared with those before treatment,and SP level was decreased when compared with that before treatment(P<0.05);the levels of BDNF and 5-HY in the observation group were higher than those in the control group and the SP level was lower(P<0.05). Conclusion: Jieyu Huatang tang has significant clinical effect in treating patients with depression after cerebral infarction, which can relive their depressive mood, improve the quality of sleep,motor function and nerve function,increase the levels of BDNF and 5-HY in serum,and reduce the SP level.

    参考文献
    相似文献
    引证文献
引用本文

陈礼军,吕曼凤,李敬贤,吴晓娟.解郁化痰汤治疗脑梗死后抑郁临床研究[J].新中医,2020,52(20):64-67

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-10-19
  • 出版日期: