补肾生血汤治疗儿童再生障碍性贫血临床研究
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R556.5

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Clinical Study on Bushen Shengxue Tang for Children with Aplastic Anemia
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    摘要:

    目的:观察补肾生血汤联合西医常规疗法治疗儿童再生障碍性贫血(AA)(肾阴虚证) 的临床疗效。方法:将90例AA患者随机分为对照组和观察组,各45例;对照组给予环孢素软胶囊、司坦唑醇片治疗,观察组在对照组治疗的基础上加用补肾生血汤加减治疗,均连续治疗6 个月;观察比较2 组治疗前后白细胞(WBC) 计数、红细胞(RBC) 计数、中性粒细胞计数(ANC)、血红蛋白(Hb) 和血小板(BPC) 水平及肾阴虚证候评分变化,并统计2 组临床疗效。结果:总有效率观察组为100%,对照组为86.67%;2组疗效经秩和检验,差异有统计学意义(P<0.05),观察组疗效优于对照组。治疗后,2组患儿外周血WBC、RBC、Hb 和BPC 均较治疗前明显升高(P<0.05),且观察组患儿WBC、RBC、Hb、BPC 水平均高于对照组(P<0.05)。治疗后,2 组患儿肾阴虚证候评分均较治疗前明显降低(P<0.05),且观察组证候评分明显低于对照组(P<0.05)。结论:在环孢素软胶囊等常规治疗的基础上联合补肾生血汤治疗儿童AA(肾阴虚证),可增强骨髓造血能力,改善患儿中医证候,疗效优于单纯西治疗。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Bushen Shengxue tang combined with routine western medicine therapy for children with aplastic anemia(AA) with kidneyyin deficiency syndrome. Methods:A total of 90 cases of AA patients were randomly divided into the control group and the observation group, 45 cases in each group. The control group was treated with cyclosporine soft capsules and stanozolol tablets, and the observation group was additionally treated with modified Bushen Shengxue tangbased on the treatment of the control group. Both groups were treated for six months. The changes of the levels of white blood cell(WBC) count, red blood cell(RBC) count, absolute neutrophil count(ANC), hemoglobin(Hb) and platelet(BPC) as well as the scores of kidneyyin deficiencysyndrome before and after treatment in the two groups were observed and compared;and the clinical effect in the two groups was recorded. Results:The total effective rate was 100% in the observation group and 86.67% in the control group,the difference being significant(P<0.05),and the curative effect in the observation group was better than that in the control group. After treatment,the levels of WBC,RBC,Hb and BPC in peripheral blood in the two groups were significantly increased when compared with those before treatment (P<0.05), and the above levels in the observation group were all higher than those in the control group(P<0.05). After treatment,thescores of kidneyyin deficiency syndrome in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the score in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Based onroutine treatment of CsA, the additional application of Bushen Shengxue tang for AA children with kidneyyin deficiency syndrome can enhance the hematopoietic ability of bone marrow and improve the Chinese medicine syndromes,whose curative effect is better than that of simple western medicine.

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陈兴华.补肾生血汤治疗儿童再生障碍性贫血临床研究[J].新中医,2020,52(12):107-109

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  • 在线发布日期: 2020-06-15
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