养心醒脑汤联合齐拉西酮治疗精神分裂症疗效及安全性研究
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R749.3

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Study on Effect and Safety of Yangxin Xingnao Tang Combined with Ziprasidone for Schizophrenia
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    摘要:

    目的:观察养心醒脑汤联合齐拉西酮治疗精神分裂症的疗效及用药安全性。方法:将心脾两虚型精神分裂症患者240例按照随机数字表法分为对照组和观察组各120例,对照组给予盐酸齐拉西酮片治疗,观察组给予盐酸齐拉西酮片联合养心醒脑汤治疗,2 组均连续治疗8 周。比较2 组治疗前后阳性与阴性症状量表(PANSS) 评分、社会功能评定量表(SSPI) 评分,观察不良反应,评价疗效。结果:对照组有效率为72.50%,观察组有效率为90.00%。观察组有效率高于对照组,差异有统计学意义(χ2=12.062,P<0.05)。经过治疗,2 组PANSS 评分较前改善,观察组PANSS 评分低于对照组,差异有统计学意义(P<0.05)。经过治疗,2组SSPI评分较前改善,观察组SSPI评分高于对照组,差异有统计学意义(P<0.05)。对照组不良反应率为28.33%,观察组不良反应率为10.83%,观察组不良反应率低于对照组,差异有统计学意义(χ2=11.668,P<0.05)。结论:养心醒脑汤联合齐拉西酮治疗心脾两虚型精神分裂症患者,疗效显著,可明显改善患者症状,提高社会功能,并且不良反应少,安全性高。

    Abstract:

    Abstract:Objective:To observe the effect of Yangxin Xingnao tang combined with ziprasidone on schizophrenia,and its safety. Methods:A total of 240 cases of patients with schizophrenia of heart- spleen deficiency type were divided into the control group and the observation group according to the random number table method,120 cases in each group. The control group was given ziprasidone hydrochloride tablets,and the observation group was additionally treated with Yangxin Xingnao tang. Both groups were continuously treated for eight weeks. The scores of Positive and Negative Syndrome Scale(PANSS) and Social Skills for Psychiatric Inpatients(SSPI) before and after treatment in the two groups were compared. The adverse reactions were observed. The curative effect was evaluated. Results: The total effective rate was 72.50% in the control group, lower than that of 90.00% in the observation group, the difference being significant(χ 2=12.062, P<0.05). After treatment,the scores of PANSS in the two groups were improved when compared with those before treatment,and the score in the observation group was lower than that in the control group, the difference being significant(P<0.05). After treatment,the scores of SSPI in the two groups were improved when compared with those before treatment,and the score in the observation group was higher than that in the control group,the difference being significant(P<0.05). The incidence of adverse reactions was 28.33% in the control group, higher than that of 10.83% in the observation group, the difference being significant(χ 2=11.668, P<0.05). Conclusion: The therapy of Yangxin Xingnao tang combined with ziprasidone has significant curative effect in treating patients with schizophrenia of heart-spleen deficiency type,which can efficiently relieve their symptoms and improve the social skills,with few adverse reactions and high safety.

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夏花.养心醒脑汤联合齐拉西酮治疗精神分裂症疗效及安全性研究[J].新中医,2020,52(12):64-66

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  • 在线发布日期: 2020-06-15
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