中药熏洗联合血液透析与炉甘石洗剂治疗尿毒症伴皮肤瘙痒临床研究
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Clinical Study on Chinese Herbal Fumigation Combined with Hemodialysis and Calamine lotion for Uremia Patients with Skin Pruritus
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    摘要:

    目的:观察中药熏洗联合血液透析与炉甘石洗剂治疗尿毒症伴皮肤瘙痒的效果。方法:选取120 例尿毒症伴皮肤瘙痒患者,采用随机数字表法分为对照组与治疗组各60 例。2 组均给予相同的基础治疗,即调整饮食结构与生活习惯、控制基础疾病,对照组采用血液透析与炉甘石洗剂治疗,治疗组在对照组基础上联合中药熏洗治疗。4 周为1 个疗程,2 组均连续治疗2 个疗程。比较2 组治疗前后四项目瘙痒量表(FIIQ) 评分、中医证候评分、血肌酐(SCr)、血磷(P)、血尿素氮(BUN)、5-羟色胺(5-HT) 水平,评价2 组临床疗效,记录不良反应发生情况。结果:治疗后,2 组FIIQ 及中医证候评分均较治疗前降低(P<0.05);治疗组FIIQ 及中医证候评分均低于对照组(P<0.05)。治疗后,2 组SCr、BUN、血P 及5-HT 水平均较治疗前降低(P<0.05);治疗组SCr、BUN、血P、5-HT 水平均低于对照组(P<0.05)。对照组总有效率为68.33%,低于治疗组的88.33%,差异有统计学意义(P<0.05)。2 组均未见明显不良反应。结论:中药熏洗联合血液透析与炉甘石洗剂治疗尿毒症伴皮肤瘙痒,能改善肾功能,并抑制5-HT 表达,从而改善患者瘙痒症状,安全性好。

    Abstract:

    Abstract:Objective:To observe the effect of the therapy of Chinese herbal fumigation combined with hemodialysis and calamine lotion on skin pruritus in patients with uremia. Methods: A total of 120 uremia patients with skin pruritus were selected and divided into the control group and the treatment group according to the random number table method,60 cases in each group. Both groups were given the same basic treatment,that is,adjusting diet and lifestyle,and controlling basic diseases. The control group was treated with hemodialysis and calamine lotion, and the treatment group was additionally treated with Chinese herbal fumigation based on the treatment of the control group. Both groups were treated for two courses, four weeks being one course. Before and after treatment, the score of Four- Item Itch Questionnaire(FIIQ), Chinese medicine syndrome score,the levels of serum creatinine(SCr),phosphorus(P),blood urea nitrogen(BUN) and intact 5-hydroxytryptamine(5-HT) were compared between the two groups. The clinical effect in the two groups was evaluated and adverse reactions were recorded. Results: After treatment, the scores of FIIQ and Chinese medicine syndrome were decreased in both groups(P<0.05),and the above two scores in the treatment group were lower than those in the control group(P<0.05). After treatment,the levels of SCr,BUN,P and 5- HT were decreased in both groups(P<0.05),and the levels of SCr, BUN, P and 5- HT in the treatment group were lower than those in the control group(P<0.05). The total effective rate in the control group was 68.33% , lower than that of 88.33% in the treatment group, the difference being significant(P<0.05). No significant adverse reactions were observed in the 2 groups. Conclusion:Chinese herbal fumigation combined with hemodialysis and calamine lotion in the treatment of uremic patients with pruritus can improve renal function and inhibit the expression of 5-HT,thus improving the pruritus symptoms of patients with good safety.

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王先锋.中药熏洗联合血液透析与炉甘石洗剂治疗尿毒症伴皮肤瘙痒临床研究[J].新中医,2020,52(19):111-113

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  • 在线发布日期: 2020-10-12
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