水飞蓟宾联合多烯磷脂酰胆碱治疗非酒精性脂肪肝临床研究
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R575.5

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Clinical Study on Silibinin Combined with Polyene Phosphatidylcholine for Nonalcoholic Fatty Liver Disease
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    摘要:

    目的:观察水飞蓟宾联合多烯磷脂酰胆碱治疗非酒精性脂肪肝(NAFLD) 的效果。方法:选取140 例NAFLD 患者,按照随机数字表法分成2 组各70 例。2 组均控制饮食,并通过锻炼控制体质量,对照组给予多烯磷脂酰胆碱胶囊口服,观察组在对照组的基础上加用水飞蓟宾胶囊口服,2 组疗程均为3 个月。比较2 组治疗前后的血脂、肝功能、血糖相关指标,评价临床疗效,观察不良反应情况。结果:治疗后,2 组碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)、γ-谷氨酸转肽酶(GGT)、天冬氨酸转氨酶(AST) 水平均较治疗前降低(P<0.05);观察组ALP、ALT、GGT、AST 水平均低于对照组(P<0.05)。治疗后,对照组高密度脂蛋白胆固醇(HDL-C) 水平较治疗前升高(P<0.05);对照组低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC) 水平较治疗前降低(P<0.05);观察组HDL-C 水平较治疗前升高,且高于同期对照组(P<0.05);观察组LDL-C、TG、TC、空腹胰岛素(FINS) 水平及胰岛素抵抗稳态指数(HOMA-IR) 均较治疗前降低,且均低于同期对照组(P<0.05)。对照组总有效率为71.43%,观察组总有效率为85.71%,观察组总有效率高于对照组(P<0.05)。2 组均无明显不良反应发生。结论:水飞蓟宾联合多烯磷脂酰胆碱治疗NAFLD,能够改善患者血脂和胰岛素抵抗程度,保护肝功能,安全性良好。

    Abstract:

    Abstract:Objective:To observe the effect of silibinin capsules combined with polyene phosphatidylcholine capsules for nonalcoholic fatty liver disease(NAFLD). Methods: A total of 140 cases of NAFLD patients were divided into two groups according to the random number table method, 70 cases in each group. Both groups were given diet control and weight control by exercise, the control group was given oral administration of polyene phosphatidylcholine capsules, and the observation group was additionally given oral administration of silibinin capsules. Both groups were treated for three months. Before and after treatment,the indexes of blood lipid,liver function and blood glucose in the two groups were compared. The clinical effect was evaluated and the adverse reactions were observed. Results:After treatment,the levels of alkaline phosphatase(ALP),alanine aminotransferase(ALT),γ-glutamyl transferase(GGT) and aspartate aminotransferase(AST) in the two groups were decreased when compared with those before treatment(P<0.05);and the levels in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of high-density lipoprotein cholesterol(HDL-C) in the control group was increased when compared with that before treatment(P<0.05), and the levels of low- density lipoprotein cholesterol(LDL-C),triglyceride(TG) and total cholesterol(TC) in the control group were decreased(P<0.05);the HDL-C level in the observation group was increased when compared with that before treatment,and higher than that in the control group at the same period(P<0.05),and the levels of LDL-C,TG,TC and fasting insulin(FINS) as well as homeostatic model assessment for insulin resistance(HOMA-IR) were decreased when compared with those before treatment,and were lower than those in the control group at the same period(P<0.05). The total effective rate was 85.71% in the observation group,higher than that of 71.43% in the control group(P<0.05). There was no obvious adverse reaction in the two groups. Conclusion: Silibinin capsules combined with polyene phosphatidylcholine capsules for NAFLD can improve blood lipid and insulin resistance and protect liver function with good safety.

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杨亚莉,张志强,魏毅强.水飞蓟宾联合多烯磷脂酰胆碱治疗非酒精性脂肪肝临床研究[J].新中医,2020,52(19):81-84

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  • 在线发布日期: 2020-10-12
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