| 摘要: |
| 目的：观察血必净注射液治疗慢性阻塞性肺疾病（COPD） 合并重症感染的临床疗效及对血清炎症因子的影响。方法：将COPD 合并重症感染患者98 例随机分为对照组与观察组，对照组49 例采取无创机械通气治疗，观察组49 例采取无创机械通气联合血必净注射液治疗。观察比较2 组治疗前后动脉血二氧化碳分压（PaCO2）、血氧分压（PaO2）、急性生理与慢性健康评分表（APACHE-Ⅱ） 评分及炎症因子C-反应蛋白（CRP）、白细胞介素-6（IL-6） 与降钙素原（PCT） 水平变化，并统计2 组临床疗效。结果：总有效率观察组为81.6%，对照组为53.1%，2 组比较，差异有统计学意义（P＜0.05）。治疗后2 组患者PaCO2、APACHE-Ⅱ评分均较治疗前下降（P＜0.05），PaO2 较治疗前上升（P＜0.05），且观察组上述各项指标改善较对照组更显著（P＜0.05）。治疗后，2 组CRP、IL-6、PCT 水平均较治疗前降低（P＜0.05），且观察组上述各项指标均低于对照组（P＜0.05）。结论：血必净注射液联合无创机械通气治疗COPD 合并重症感染，可显著增加血氧浓度，降低血清炎症介质的释放，从而改善急性肺损伤，疗效优于单纯传统无创机械通气治疗。 |
| 关键词: 慢性阻塞性肺疾病 重症感染 无创机械通气 血必净注射液 炎症因子 APACHE-Ⅱ评分 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Xuebijing Injection for Chronic Obstructive Pulmonary DiseaseComplicated with Severe Infection |
| LYU Mingming,ZHANG Bin,YE Chuanchuan |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract： Objective： To observe the clinical effect of Xuebijing injection for chronic obstructive pulmonary disease
(COPD) complicated with severe infection and its effect on inflammatory factors in serum. Methods：A total of 98 cases of
patients with COPD complicated with severe infection were randomly divided into the control group and the observation
group，49 cases in each group. The control group was given noninvasive mechanical ventilation，and the observation group
was additionally given Xuebijing injection. The changes in arterial partial pressure of carbon dioxide(PaCO2)， arterial partial
pressure of oxygen(PaO2)，the scores of Acute Physiology and Chronic Health Evaluation Scale- Ⅱ(APACHE-Ⅱ)，and the
levels of inflammatory factors including C- reactive protein(CRP)，interleukin- 6(IL- 6) and plasma calcitonin(PCT) in the two
groups were observed and compared before and after treatment. The clinical effect in the two groups was counted. Results：
The total effective rate was 81.6% in the observation group and 53.1% in the control group，the difference being significant
(P＜0.05). After treatment，PaCO2 and the scores of APACHE-Ⅱ in the two groups were decreased when compared with
those before treatment(P＜0.05)， and PaO2 were increased when compared with those before treatment(P＜0.05)； the
improvement of each index above in the observation group was more significant than that in the control group(P＜0.05). After
treatment，the levels of CRP，IL-6 and PCT in the two groups were decreased when compared with those before treatment
(P＜0.05)，and each index above in the observation group was lower than that in the control group(P＜0.05). Conclusion：The
application of Xuebijing injection combined with noninvasive mechanical ventilation in treating COPD complicated with severe
infection，can significantly increase the concentration of blood oxygen and reduce the release of inflammatory mediators in
serum， thus improving acute injury， whose curative effect is better than that of simple traditional noninvasive mechanical
ventilation. |
| Key words: Keywords： Chronic obstructive pulmonary disease Severe infection Noninvasive mechanical ventilation Xuebijing
injection Inflammatory factors Scores of APACHE-Ⅱ |
