基于数据挖掘探讨王邦才治疗慢性泄泻用药规律研究
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R256.34

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浙江省王邦才名老中医传承工作室(GZS2017018)


Discussion on Administration Rules of WANG Bangcai's Treating Chronic Diarrhea Based on Data Mining
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    摘要:

    目的:总结王邦才教授治疗慢性泄泻的临床经验及用药规律,为中医治疗慢性泄泻的科研及临床工作提供思路及参考。方法:通过收集2015年11月—2017年12月宁波市中医院内科专家门诊王邦才教授接诊且符合慢性泄泻诊断标准的200例慢性泄泻患者的处方,利用“中医传承辅助平台系统(V2.5) ”进行数据挖掘,釆用该软件集成的频次统计法、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,对其治疗慢性泄泻的处方用药经验进行分析研究。结果:共纳入首诊处方200首,收录药物112味,治疗慢性泄泻常用药为木香、白扁豆、黄连、炒白术、干姜等,常用中药以清热药、补虚药、利水渗湿药、解表药、收涩药为主。四气以温为主,五味以甘居多,归经以脾经居首位。基于关联规则分析,挖掘出39条高频药物组合,9 条关联规则。基于复杂系统熵聚类的核心组合分析,核心组合有20 个。基于无监督的熵层次聚类的新处方分析,得到10 首新处方。结论:王邦才教授在治疗慢性泄泻时,总体用药以甘、温为主,主归脾胃经,可以体现气血同调法、温清并用法、补泄兼施法、重镇安神法。

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    Abstract: Objective: To summary the clinical experience and administration rules of Professor Wang Bangcai in the treatment of chronic diarrhea,and to provide thinking and reference for the scientific research and clinical practice of Chinese medicine treatment of disease. Methods: The prescriptions of 200 patients with chronic diarrhea were collected. These patients,in accordance with the diagnostic criteria of chronic diarrhea,were treated by Professor WANG in Ningbo Hospital of Traditional Chinese Medicine from November, 2015 to December, 2017. The prescriptions were used for data mining through Chinese Medicine Inheritance Support System(V2.5). The administration rules of Professor WANG in treating chronic diarrhea were analyzed and studied by the statistics of frequency method, the improved mutual information method,complex system entropy cluster and unsupervised hierarchical cluster, etc. Results: A total of 200 prescriptions and 112 kinds of Chinese herbs were enrolled. The commonly- used herbs in treating chronic diarrhea included Radix Aucklandiae,Semen Lablab Album, Rhizoma Coptidis, stir- bake Rhizoma Atractylodis Macrocephalae and Rhizoma Zingiberis, which mainly involved deficiency-tonifying medicine,heat-clearing medicine,dampness-resolving medicine,exterior-releasing medicine and astringent medicine. The main property of Chinese herbs was warmth,and the major flavor was sweetness.The spleen meridian ranked first in meridian tropism. There were 39 high-frequency medicine combinations and 9 association rules according to the analysis of association rules,20 core medicine combinations based on the analysis of complex system entropy cluster, and 10 new prescriptions based on the analysis of unsupervised hierarchical cluster. Conclusion: In the treatment of chronic diarrhea,Professor Wang mainly used Chinese herbs which have the flavor of sweetness,the nature of warmth, and tropism of the spleen meridian and the stomach meridian. It shows the qi- blood regulation method, both warming and clearing method,both tonifying and discharging method,and calming mind by heavy settling method.

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王丽娜,指导:王邦才.基于数据挖掘探讨王邦才治疗慢性泄泻用药规律研究[J].新中医,2020,52(10):178-182

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  • 在线发布日期: 2020-05-26
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