Abstract： Objective： To discuss the curative effect of Yupingfeng oral liquid and point application combined with sacubitril and valsartan for patients with heart failure of qi- yin deficiency type and its effect on their spirit and quality of life. Methods：A total of 150 cases of patients with heart failure were randomly divided into the combination group and the control group，75 cases in each group. The control group was given sacubitril valsartan sodium tablets，and the combination group was additionally treated with Yupingfeng oral liquid and point application with Fructus Evodiae based on the treatment of the control group. The heart function， quality of life， negative emotions， as well as the major adverse cardiovascular events (MACE) and all- cause death of follow- up patients were observed. Results： Before treatment， compared the scores of LVEF， 6MWT and MLWHFQ between the two groups， there was no significance in the difference(P＞0.05). After treatment，the scores of LVEF and 6MWT in the combination group were better than those in the control group，and the score of MLWHFQ was lower than that in the control group(P＜0.05). Before treatment， compared the levels of NTproBNP， ICAM-1 and ALD between the two groups，there was no significance in the difference(P＞0.05)；after treatment， the above three levels in the combination group were lower than those in the control group(P＜0.05). Before treatment， compared the scores of SAS and SDS between the two groups，there was no significance in the difference(P＞0.05)；after treatment， the above two scores in the combination group were lower than those in the control group(P＜0.05). During treatment，the incidence of adverse reactions was 10.67% in the combination group，and 9.33% in the control group，there being no significance in the difference(χ 2=0.074，P=0.785). During one-year follow-up，there were three cases lost in the combination group， and two cases in the control group； the incidence of MACE was 28.57% (20/72) in the combination group，and 42.46%(31/73) in the control group，the difference being significant(Log-rank χ 2=4.066，P=0.044). During oneyear follow- up，the mortality rate was 15.27%(11/72) in the combination group，and 16.44%(12/73) in the control group， there being no significance in the difference(Log-rank χ 2=0.062，P=0.804). Conclusion：For patients with heart failure of qiyin deficiency type， the therapy of Yupingfeng oral liquid and point application combined with Sacubitril and Valsartan can significantly improve their quality of life and the heart function，and relieve their negative emotions，with lower risk of MACE.