舒肝解郁胶囊联合草酸艾司西酞普兰治疗抑郁症临床研究
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R749.4+1

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浙江省玉环市科学技术局课题(2018078)


Clinical Study of Shugan Jieyu Granules Combined with Escitalopram Oxalate for Depression
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    摘要:

    目的:观察舒肝解郁胶囊联合草酸艾司西酞普兰片治疗抑郁症的临床效果及对神经功能因子的影响。方法:将抑郁症患者62例随机分为西药组和中西医结合组,每组31例;西药组采用草酸艾司西酞普兰片治疗,中西医结合组在对照组的基础上加用舒肝解郁胶囊治疗;观察比较2组治疗前后汉密尔顿抑郁量表(HAMD) 评分、神经功能相关因子[S100B蛋白、髓磷脂碱性蛋白(MBP)] 变化;观察比较2组临床总体疗效及不良反应。结果:总有效率中西医结合组为93.54%,西药组为74.19%,2组比较,差异有统计学意义(P<0.05)。治疗后4周、8周,2组患者HAMD评分均较治疗前明显下降(P<0.05);且中西医结合组HAMD评分下降较西药组更显著(P<0.05)。治疗后8W,2组患者S100B、MBP水平均较治疗前明显降低(P<0.05);但上述指标2组间比较,差异均无统计学意义(P>0.05)。不良反应发生率中西医结合组为12.90%,西药组为16.12%,2组比较,差异无统计学意义(P>0.05)。结论:在草酸艾司西酞普兰片治疗的基础上加用舒肝解郁胶囊治疗抑郁症,可有效提高临床疗效,改善患者抑郁状态,且不增加药物不良反应。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Shugan Jieyu granules combined with escitalopram oxalate for depression and its effect on factors of nerve function. Methods: A total of 62 cases of patients with depression were randomly divided into the western medicine group and the integrated Chinese and western medicine group,31 cases in each group. The western medicine group was treated with escitalopram oxalate tablets,and the integrated Chinese and western medicine group was additionally treated with Shugan Jieyu granules based on the treatment of the western medicine group. The scores of Hamilton Depression Scale(HAMD) and the changes of correlation factors of nerve function including S100B protein and myelin basic protein(MBP) before and after treatment,as well as the total clinical effect and adverse reactions in the two groups were observed and compared. Results:The total effective rate was 93.54% in the integrated Chinese and western medicine group and 74.19% in the western medicine group, the difference being significant(P<0.05). After treatment for four and eight weeks,the HAMD scores in the two groups were significantly decreased when compared with those before treatment(P<0.05);the decrease in the integrated Chinese and western medicine group was more significant than that in the western medicine group(P<0.05). After treatment for eight weeks,the levels of S100B and MBP in the two groups were significantly decreased when compared with those before treatment(P<0.05);but no significant difference was found in the comparison of the above levels between the two groups(P>0.05). The incidence of adverse reactions was 12.90% in the integrated Chinese and western medicine group and 16.12% in the western medicine group,there being no significance in the difference(P>0.05). Conclusion: Based on the treatment of escitalopram oxalate tablets, the additional application of Shugan Jieyu granules in treating depression can effectively improve clinical effect and depression state, without increasing adverse reactions of medicines.

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陈礼贤,徐丹红,王涛,翁小娟.舒肝解郁胶囊联合草酸艾司西酞普兰治疗抑郁症临床研究[J].新中医,2020,52(9):56-58

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  • 在线发布日期: 2020-05-09
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