基于“寒毒”理论探讨温阳益气解毒方治疗溃疡性结肠炎临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R574.1

基金项目:


Discussion on the Clinical Study on Yang-warming and Qi-benefiting and Detoxificating Prescription for Ulcerative Colitis Based on the Theory of"T oxic Cold"
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察温阳益气解毒方治疗溃疡性结肠炎(UC)临床疗效,探讨修复肠黏膜的可能机制。方法:选择120例UC患者,按随机数字表法分为观察组和对照组各60例。对照组给予双歧杆菌三联活菌胶囊、谷氨酰胺肠溶胶囊、美沙拉嗪肠溶片治疗,观察组在对照组基础上加用温阳益气解毒方口服。治疗后比较2组中医证候积分、临床疗效、白细胞介素-1(IL-1β)、肿瘤坏死因子-α(TNF-α)、三叶因子3(TFF3)、黏蛋白2(MUC2)及肠黏膜评分。结果:观察组总有效率为90.0%,显著高于对照组76.7%(P<0.05)。治疗前,2组单个中医症状积分比较,差异无统计学意义(P>0.05)。治疗后,2组腹痛、腹泻、脓血便、里急后重等症状评分低于治疗前,且观察组各个症状评分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组IL-1β、TNF-α、TFF3、MUC2水平比较,差异无统计学意义(P>0.05)。治疗后,2组IL-1β、TNF-α水平较治疗前降低,TFF3、MUC2水平较治疗前升高;且观察组IL-1β、TNF-α水平低于对照组,TFF3、MUC2水平高于对照组;差异均有统计学意义(P<0.05)。治疗前,2组肠黏膜评分比较,差异无统计学意义(P>0.05)。治疗后,2组肠黏膜评分较治疗前降低,且观察组肠黏膜评分低于对照组,差异均有统计学意义(P<0.05)。结论:温阳益气解毒方可以提高UC治疗效果,且可以降低IL-1β、TNF-α表达,减轻炎性反应,增加TFF3、MUC2表达量,保护肠黏膜。

    Abstract:

    Objective:To observe the clinical effect of yang-warming and qi-benefiting and detoxificating prescription for ulcerative colitis(UC)and discuss the possible mechanism of repairing the intestinal mucosa.Methods:Selected 120 cases of patients with UC and divided them into the observation group and the control group according to the random number table,with 60 cases in each group.Both groups were treated with bifidobacterium triple viable capsules,glutamine enteric-coated capsules and mesalazine enteric-coated tablets,while the observation group was additionally given the oral administration of yang-warming and qi-benefiting and detoxificating prescription.After treatment,compared the Chinese medicine syndrome scores,clinical effect,interleukin-1(IL-1β),tumor necrosis factor- α(TNF- α),trefoil factor 3(TFF3),mucin 2(MUC2)and intestinal mucosa scores in the two groups.Results:The total effective rate in the observation group was 90.0%,being evidently higher than that of 76.7% in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the single Chinese medicine syndrome scores in the two groups(P > 0.05).After treatment,the symptom scores of abdominal pain,diarrhea,mucopurulent stool and tenesmus in the two groups were lower than those before treatment and the scores of each symptom in the observation group were lower than those in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of IL-1β,TNF-α,TFF3,MUC2 in the two groups(P > 0.05).After treatment,the levels of IL-1β and TNF-α in the two groups were decreased when compared with those before treatment,while the levels of TFF3 and MUC2 were increased when compared with those before treatment;the levels of IL-1β and TNF-α in the observation group were lower than those in the control group and the levels of TFF3 and MUC2 were higher than those in the control group;the differences were significant(P < 0.05).Before treatment,there was no significant difference being found in the comparison of the intestinal mucosa scores in the two groups(P> 0.05).After treatment,the intestinal mucosa scores in the two groups ware decreased when compared with those before treatment and the intestinal mucosa scores in the observation group were lower than those in the control group,differences being significant(P<0.05).Conclusion:The application of yang-warming and qibenefiting and detoxificating prescription can improve the curative effect of UC,reduce the expressions of IL-1β and TNF-α,relieve the inflammatory reactions,enhance the expressions of TFF3 and MUC2,protect the intestinal mucosa.

    参考文献
    相似文献
    引证文献
引用本文

孙建新,张相安.基于“寒毒”理论探讨温阳益气解毒方治疗溃疡性结肠炎临床研究[J].新中医,2020,52(2):72-75

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-01-14
  • 出版日期: