杞菊地黄丸联合玻璃酸钠滴眼液治疗气阴两虚型干眼症临床研究
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Clinical Study on Qiju Dihuang Pills Combined with Sodium Hyaluronate Eye Drops for Dry Eyes of Qi-Yin Deficiency Type
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    摘要:

    目的:观察杞菊地黄丸联合玻璃酸钠滴眼液治疗干眼症的临床疗效。方法:选取180 例气阴两虚型干眼症患者,按随机数字表法分为对照组和观察组各90 例。2 组患者均给予抗炎、人工泪液、修复角膜损伤等常规治疗,对照组使用玻璃酸钠滴眼液进行治疗,观察组给予杞菊地黄丸联合玻璃酸钠滴眼液治疗。比较2 组临床疗效及泪膜破裂时间(BUT)、泪液分泌试验(SIT)、干眼症状评分、单眼角膜荧光素染色评分的变化情况。结果:观察组总有效率为95.56%,高于对照组86.67%。差异有统计学意义(P<0.05)。治疗前,2 组BUT、SIT 水平比较,差异无统计学意义(P>0.05)。治疗2 周、4 周后,2 组BUT、SIT 水平逐渐升高,且观察组BUT、SIT 水平均高于同时间点对照组,差异均有统计学意义(P<0.05)。治疗前,2 组干眼症状评分、单眼角膜荧光素染色评分比较,差异无统计学意义(P>0.05)。治疗2 周、4 周后,2 组干眼症状评分、单眼角膜荧光素染色评分逐渐降低,且观察组干眼症状评分、单眼角膜荧光素染色评分均低于同时间点对照组,差异均有统计学意义(P<0.05)。结论:杞菊地黄丸联合玻璃酸钠滴眼液治疗干眼症,能够明显改善眼部症状,提高泪膜稳定性,临床疗效较好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Qiju Dihuang pills combined with sodium hyaluronate eye drops for dry eyes. Methods:A total of 180 cases of patients with dry eyes of qi-yin deficiency type were divided into the control group and the observation group according to the random number table method,90 cases in each group. Both groups were given routine treatments such as anti- inflammation, artificial tears and repair of corneal wound. The control group was given sodium hyaluronate eye drops,and the observation group was given Qiju Dihuang pills combined with sodium hyaluronate eye drops. The clinical effect, and the changes in the tear break- up time(BUT), the Schirmer's Test(SIT), the symptom scores of dry eyes,and the scores of fluorescein staining of a single eye cornea were compared between the two groups. Results:The total effective rate was 95.56% in the observation group,higher than that of 86.67% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of BUT and SIT between the two groups(P>0.05). After two-week and four-week treatment,the levels of BUT and SIT in the two groups were gradually increased,and the two levels in the observation group were higher than those in the control group at the same time point, differences being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of the symptom scores of dry eyes and the scores of fluorescein staining of a single eye cornea between the two groups(P>0.05). After two-week and four-week treatment,the symptom scores of dry eyes and the scores of fluorescein staining of a single eye cornea in the two groups were gradually decreased,and the two scores in the observation group were lower than those in the control group at the same time point,differences being significant (P<0.05). Conclusion:The therapy of Qiju Dihuang pills combined with sodium hyaluronate eye drops in treating dry eyes, can significantly improve the eye symptoms,and increase stability of tear film with better clinical effect.

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沙恒.杞菊地黄丸联合玻璃酸钠滴眼液治疗气阴两虚型干眼症临床研究[J].新中医,2020,52(18):50-53

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  • 在线发布日期: 2020-09-20
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