逍遥散加减方对老年性干眼症患者眼表功能及血清细胞因子的影响
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R777.3

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Effect of Modified Prescription of Xiaoyao Powder on Function of Ocular Surface and Cytokines in Serum of Senile Patients with Dry Eye
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    摘要:

    目的:探究逍遥散加减方对老年性干眼症患者眼表功能及血清细胞因子的影响。方法:选取86例老年性干眼症患者,按随机数字表法分为对照组和观察组各43例。对照组采用妥布霉素地塞米松滴眼液治疗,观察组在对照组基础上给予逍遥散加减方水煎服。观察2组的症状评分、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、血管内皮生长因子(VEGF)、色素上皮衍生因子(PEDF)、胰岛素样生长因子-1(IGF-1)、组织因子(TF)、CD3+、CD4+、CD8+水平,采用视功能损害眼病患者生活质量量表(SQOL-DVI)和国家眼科研究视功能量表(NEI-VFQ-25)评价生活质量,并观察2组的临床疗效、不良反应。结果:观察组总有效率为95.35%,高于对照组81.40%(P<0.05)。治疗后,2组口干、眼干症状评分较治疗前下降(P<0.05),且观察组口干、眼干症状评分低于对照组(P<0.05)。治疗后,2组TNF-α、PEDF水平较治疗前降低(P<0.05),IFN-γ、VEGF、IGF-1、TF水平较治疗前升高(P<0.05);且观察组TNF-α、PEDF水平低于对照组(P<0.05),而IFN-γ、VEGF、IGF-1、TF水平高于对照组(P<0.05)。治疗后,2组CD3+、CD4+、CD4+/CD8+较治疗前升高(P<0.05),CD8+较治疗前降低(P<0.05);且观察组CD3+、CD4+、CD4+/CD8+高于对照组(P<0.05),而CD8+低于对照组(P<0.05)。治疗后,2组NEI-VFQ-25评分、SQOLDVI评分均较治疗前升高(P<0.05),且观察组NEI-VFQ-25评分、SQOL-DVI评分高于对照组(P<0.05)。结论:逍遥散加减方治疗老年性干眼症疗效较好,有效缓解症状,能够抑制视网膜内多种细胞因子,介导形成新生血管,抑制炎症反应,改善免疫功能,安全可靠。

    Abstract:

    Objective:To discuss the effect of modified prescription of Xiaoyao powder on function of ocular surface and cytokines in serum of senile patients with dry eye.Methods:A total of 86 cases of senile patients with dry eye were selected and divided into the control group and the observation group according to the random number table method,43 cases in each group.The control group was treated with tobramycin and dexamethasone eye drops,and the observation group was additionally treated with modified prescription of Xiaoyao powder decocted with water based on the treatment of the control group.The scores of symptoms and the levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),vascular endothelial growth factor(VEGF), pigment epithelium-derived factor(PEDF), insulin-like growth factor-1(IGF-1), tissue factor(TF),CD3+,CD4+and CD8+in the two groups were observed.The quality of life was evaluated by the Scale of Quality of Life for Patients with Visual Impairment(SQOL-DVI)and National Eye Institute 25-Item Visual Function Questionnaire(NEI-VFQ-25).The clinical effect and adverse reactions in the two groups were observed.Results:The total effective rate was 95.35% in the observation group,higher than that of 81.40% in the control group(P < 0.05).After treatment,the scores of dry mouth and dry eye in the two groups were decreased when compared with those before treatment(P < 0.05),and the above two scores in the observation group were lower than those in the control group(P < 0.05).After treatment,the levels of TNF-α and PEDF in the two groups were decreased when compared with those before treatment(P< 0.05),and the levels of IFN-γ,VEGF,IGF-1 and TF were increased when compared with those before treatment(P < 0.05);the levels of TNF-α and PEDF in the observation group were lower than those in the control group(P < 0.05),and the levels of IFN-γ,VEGF,IGF-1 and TF in the observation group were higher than those in the control group(P < 0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the two groups were increased when compared with those before treatment(P < 0.05),and the levels of CD8+in the two groups were decreased when compared with those before treatment(P < 0.05);the levels of CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P < 0.05),and the level of CD8+was lower than that in the control group(P<0.05).After treatment,the scores of NEI-VFQ-25 and SQOL-DVI in the two groups were increased when compared with those before treatment(P < 0.05),and the above two scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The modified prescription of Xiaoyao powder has good curative effect in treating dry eye of senile patients,which can effectively relieve symptoms,inhibit many cytokines in retina and inflammatory responses,mediate the formation of new blood vessels and improve immune function,with safety and reliability.

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徐辉.逍遥散加减方对老年性干眼症患者眼表功能及血清细胞因子的影响[J].新中医,2020,52(1):26-30

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  • 在线发布日期: 2020-01-06
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