Taking the equivalent or exceeding dosage of gypsum in Pharmacopoeia of the People's Republic of China as the criterion for high-dose application,in accordance with the conversion method of ancient and modern doses(1 Liang=10 Qian=30 g)in the textbooks compiled by national Chinese medicine colleges,and according to the principle of“high dose is the monarch” in Formulaology,the authors collected and sorted the public reports on the clinical treatment with composing prescriptions by applying the high dose of gypsum as a monarch or a minister so as to summarize the therapeutic effect of high-dose application of gypsum for acute-severe diseases and difficult-complicated diseases.As the results of literature research,the treatment with high-dose application of gypsum has good effect in treating all nine kinds of acute-severe diseases and difficult-complicated diseases.Regarding preliminary understandings of the high-dose application of gypsum,the high-dose efficiency continues with the past and opens up the future,which is worthy of replication studies;it is valuable that children are treated via high-dose application of gypsum,which requires the exact judgment of situation;the individual cases and reports should not be overlooked if inherited normatively;it helps to highlight its characteristics by summarizing the advantages and presenting features.