归脾汤治疗胃癌相关性轻中度贫血临床观察
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R735.2

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浙江省中医药管理局课题(2016ZB133)


Clinical Observation on Guipi Tang for Mild-to-moderate Anemia Related to Gastric Cancer
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    摘要:

    目的:观察归脾汤治疗胃癌相关性轻中度贫血的临床疗效。方法:将本院胃癌贫血患者共80例纳入研究,随机分为2组各40例。治疗组给予归脾汤为主的汤剂治疗,并根据患者情况辨证论治进行加减。对照组口服琥珀酸亚铁片治疗,并根据并发症情况给予叶酸片维生素B12片治疗。观察血红蛋白、红细胞水平、T淋巴细胞亚群及自然杀伤(NK)细胞数、体力状况KPS评分的变化,观察周期为2月。结果:治疗1月后,治疗组血红蛋白较治疗前升高,差异有统计学意义(P<0.05)。治疗2月后,2组血红蛋白、红细胞均较治疗前升高,差异均有统计学意义(P<0.05)。治疗组血红蛋白、红细胞与同期对照组比较,差异均有统计学意义(P<0.05)。治疗2月后,治疗组CD4+、CD4+/CD8+、CD16+56+均较治疗前有升高,差异均有统计学意义(P<0.05);治疗2月后,治疗组CD4+、CD4+/CD8+、CD16+56+分别与对照组比较,差异均有统计学意义(P<0.05)。治疗1月后、治疗2月后,2组KPS评分分别与治疗前比较,差异均无统计学意义(P>0.05)。结论:归脾汤治疗胃癌贫血患者,可升高血红蛋白、红细胞水平,改善贫血的效果比西医常规补铁治疗效果更好,同时归脾汤还能提高患者免疫功能。

    Abstract:

    Objective:To observe the clinical effect of Guipi tang for mild-to-moderate anemia related to gastric cancer.Methods:Eighty cases of patients with gastric cancer anemia were included in the study and were divided into two groups randomly,40 cases in each group.The treatment group received decoction which mainly included Guipi tang and was modified by the treatment based on syndrome differentiation.The control group was treated with ferrous succinate tablets orally and was additionally treated with folic acid tablets and vitamin B12tablets according to complications.Observed the changes in levels of hemoglobin and erythrocyte,T lymphocyte subsets,the number of natural killer(NK)cell and the score of karnofsly's performance status(KPS).The observation lasted for two months.Results:After treatment of one month,the level of hemoglobin in the treatment group was increased when compared with that before treatment,the difference being significant(P<0.05).After treatment of two months,levels of hemoglobin and erythrocyte in the two groups were increased when compared with those before treatment,differences being significant(P<0.05).Compared with those in the control group during the same period,levels of hemoglobin and erythrocyte in the treatment group were increased,differences being significant(P<0.05).After treatment of two months,values of CD4+,CD4+/CD8+and CD16+56+in the treatment group were increased when compared with those before treatment,differences being significant(P<0.05).After treatment of two months,compared with the values of CD4+,CD4+/CD8+and CD16+56+between the two groups respectively,differences were significant(P<0.05).After treatment of one month and two months,compared with KPS scores between the two groups before treatment,there was no significance in differences(P>0.05).Conclusion:The therapy of Guipi tang for anemia related to gastric cancer can increase the levels of hemoglobin and erythrocyte,and improve the immune function of patients,which has better effect in improving anemia than western routine treatment of iron supplement.

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彭涛,欧阳喻璐,李志丹,朱伟伟,左芬,孙锦茂,童康尔.归脾汤治疗胃癌相关性轻中度贫血临床观察[J].新中医,2018,50(12):178-180

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  • 在线发布日期: 2018-12-09
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