复方鳖甲软肝片联合阿德福韦酯治疗瘀血阻络证慢性乙型肝炎临床观察
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R512.6+2

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Clinical Observation on Compound Biejia Ruangan Tablets Combined with Adefovir Dipivoxil for Chronic Hepatitis B with Syndrome of Static Blood Blocking Collaterals
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    摘要:

    目的:观察复方鳖甲软肝片联合阿德福韦酯治疗瘀血阻络证慢性乙型肝炎(CHB)的临床疗效及对肝功能相关血清因子的影响。方法:将88例患者按随机数字表法分为2组各44例,对照组给予阿德福韦酯片抗病毒治疗,观察组在对照组治疗的基础上加用复方鳖甲软肝片治疗,2组均连续治疗1年;记录2组患者治疗前后HBV-DNA载量变化情况;比较2组患者治疗前后肝功能谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBil)、谷氨酰转肽酶(GGT)的变化,并统计分析临床疗效及不良反应发生率。结果:治疗后24、28周,2组患者HBV-DNA载量均较治疗前下降(P<0.05);且观察组HBV-DNA载量下降较对照组同时间段更显著(P<0.05)。治疗后,2组AST、ALT、TBil、GGT水平均较治疗前下降(P<0.05);且观察组上述指标水平下降较对照组更显著(P<0.05)。临床疗效总有效率观察组为86.4%,对照组为63.6%,2组比较,差异有统计学意义(P<0.05)。不良反应发生率观察组为4.5%,对照组为13.6%,2组比较,差异有统计学意义(P<0.05)。结论:阿德福韦酯片治疗的基础上加用复方鳖甲软肝片治疗瘀血阻络证型CHB,可更好地降低病毒复制,疗效优于单独西药治疗,且安全性更好。

    Abstract:

    Objective:To observe the clinical effect of compound Biejia Ruangan tablets combined with adefovir dipivoxil for chronic hepatitis B(CHB)with syndrome of static blood blocking collaterals and its effect on serum factors related to the liver function.Methods:Divided 88 cases of patients into two groups according to the random number table method,44 cases in each group.The control group was treated with adefovir dipivoxil tablets,while the observation group was additionally given compound Biejia Ruangan tablets for treatment based on the treatment of the control group.Both groups were treated for one year.Before and after treatment,recorded changes in HBV-DNA load,compared changes in serum factors related to the liver function including aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),and gamma-glutamyltransferase(GGT),and statistically analyzed the clinical effect and incidence of adverse reactions in the two groups.Results:After the 24thand 28thweeks of treatment,the HBV-DNA load in both groups was decreased when compared with that before treatment(P<0.05).The decreased of HBV-DNA load in the observation group was more obvious than that in control group at the same period(P<0.05).After treatment,levels of AST,ALT,TBil and GGT in the two groups were decreased when compared with those before treatment(P<0.05),and the decrease of levels of the above indexes in the observation group was more obvious than that in control group(P<0.05).The total effective rate was 86.4%in the observation group and 63.6%in the control group,the difference being significant(P<0.05).The incidence of adverse reactions was 4.5% in the observation group and 13.6% in the control group,the difference being significant(P<0.05).Conclusion:The therapy of compound Biejia Ruangan tablets combined with adefovir dipivoxil tablets for CHB with syndrome of static blood blocking collaterals can reduce virus replication,whose therapeutic effect is superior to that of simple western medicine with better safety.

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刘晨媛,谢志宏.复方鳖甲软肝片联合阿德福韦酯治疗瘀血阻络证慢性乙型肝炎临床观察[J].新中医,2018,50(12):92-94

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  • 在线发布日期: 2018-12-09
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