红花注射液治疗老年脑梗死疗效观察
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R743.3

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Clinical Observation on Safflower Injection for Senile Cerebral Infarction
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    摘要:

    目的:观察红花注射液治疗老年脑梗死的临床疗效。方法:将老年脑梗死患者98例按随机数字表法分为2组,对照组49例予甘露醇静滴及阿司匹林口服;观察组49例在对照组治疗的基础上联合红花注射液静脉滴注;疗程均为2周,观察比较2组临床疗效、神经损伤程度量表评分(NSS),检测血液流变学指标及血浆超敏C-反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)等变化。结果:总有效率观察组为87.86%,对照组为63.28%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组NSS评分均较治疗前降低(P<0.05);且观察组NSS评分降低较对照组更显著(P<0.05)。治疗后2组TGF-β1、hs-CRP水平较治疗前降低(P<0.05),VEGF水平较治疗前升高(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。治疗后,2组患者血浆比黏度、红细胞压积、红细胞聚集指数、纤维蛋白原均较治疗前明显下降(P<0.05);且观察组上述各项指标降低较对照组更显著(P<0.05)。结论:红花注射液治疗老年脑梗死疗效显著,可通过降低hs-CRP及TGF-β1、升高VEGF水平,进而促进患者神经功能的恢复。

    Abstract:

    Objective:To observe the clinical effect of safflower injection for senile cerebral infarction.Methods:Divided 98 cases of patients with senile cerebral infarction into two groups randomly,46 cases in each group.The control group was given mannitol by intravenous drip and aspirin by oral administration,while the observation group was additionally given safflower injection by intravenous drip.The course of treatment lasted for 2 weeks.Observed and compared the clinical effect and neurological severity scores(NSS)in both groups,and detected the changes of hemodynamic index,plasma high sensitive C-reactive protein(hsCRP),vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGF-β1).Results:The total effective rate was 87.86%in the observation group and 63.28%in the control group,difference being significant(P<0.05).After treatment,scores of NSS in both groups were lower than those before treatment(P<0.05); the scores of NSS in the observation group were decreased more significantly than those in the control group(P<0.05).After treatment,the levels of TGF-β1 and hsCRP in both groups were lower than those before treatment(P<0.05),and the level of VEGF was higher than that before treatment(P<0.05);the indexes above in the observation group were improved more than those in the control group(P<0.05).After treatment,such indexes as plasma viscosity,hematocrit,erythrocyte aggregation index and fibrinogen of patients in both groups were significantly lower than those before treatment(P<0.05);each index above in the observation group was decreased more significantly than that in the control group(P<0.05).Conclusion:Safflower injection has significant clinical effect in treating senile cerebral infarction,which can promote the recovery of neurological function of patients by decreasing the levels of hsCRP and TGF-β1 as well as increasing the level of VEGF.

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朱先州,王静敏.红花注射液治疗老年脑梗死疗效观察[J].新中医,2018,50(12):66-68

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  • 在线发布日期: 2018-12-09
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