祛瘀泄浊汤加减联合西药治疗慢性肾功能衰竭临床疗效观察
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R692.5

基金项目:


Observation of Modified Quyu Xiezhuo Tang Combined with Western Medicine for Chronic Renal Failure
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察祛瘀泄浊汤加减联合西药治疗慢性肾功能衰竭的临床疗效。方法:将84例慢性肾功能衰竭气虚血瘀、湿浊内蕴证患者随机分为对照组和观察组,对照组在治疗原发性疾病的基础上加用复方α-酮酸片,观察组在对照组的基础上辨证使用祛瘀泄浊汤,2组均连续治疗3月,观察2组患者主要症状的变化情况与不良反应发生情况,检测2组患者的肾功能指标[肌酐(SCr)、血尿素氮(BUN)、血尿酸(UA)、内生肌酐清除率(CCr)]和血液流变学指标。结果:治疗后,观察组总有效率为83.3%,对照组总有效率为54.8%,2组比较,差异有统计学意义(P<0.01)。2组SCr、UA、BUN均较治疗前降低,CCr均较治疗前升高,差异均有统计学意义(P<0.05);观察组SCr、UA、BUN低于对照组,CCr高于对照组,差异均有统计学意义(P<0.05)。2组血浆纤维蛋白原、血浆黏度和红细胞聚集指数均较治疗前下降,差异均有统计学意义(P<0.05);观察组血浆纤维蛋白原、血浆黏度和红细胞聚集指数均低于对照组,差异均有统计学意义(P<0.05)。结论:在常规治疗的基础上辨证使用祛瘀泄浊汤,可使患者的肾功能显著改善,临床疗效得到提高,且安全性较好,具有较大的临床借鉴意义。

    Abstract:

    Objective:To observe the clinical effect of modified Quyu Xiezhuo tang combined with western medicine for chronic renal failure.Methods:Selected 84 cases of patients with chronic renal failure with the syndrome of qi deficiency and blood stasis as well as endogenous pathogenic dampness,and divided them into the observation group and the control group randomly.Based on the treatment of primary diseases,the control group was given compound α-ketoacid tablets,while the observation group additionally receivedmodified Quyu Xiezhuo tang apart from the same treatment in the control group.Both groups continuously received the treatment for 3 months.Observed changes of main symptoms and adverse reaction in both groups.Determined the renal function indexes[serum creatinine(SCr),blood urine nitrogen(BUN), uric acid(UA), and endogenous creatinine clearance(CCr)]as well as hemoreology indexes in both groups.Results:After treatment,the total effective rate was 83.3%in the control group and 54.8%in the observation group,the difference being significant(P<0.05).Levels of SCr,UA and BUN in both groups were reduced when compared with those before treatment,while levels of CCr were increased when compared with those before treatment,differences being significant(P < 0.05).Levels of SCr,UA,BUN,and CCr in the observation group were all superior to those in the control group,differences being significant(P<0.05).Plasma fibrinogen,plasma viscosity and erythrocyte aggregation indexes in both groups were all declined,comparing with those before treatment,differences all being significant(P < 0.05).The three indexes in the observation group were all lower than those in the control group,differences being significant(P < 0.05).Conclusion:The therapy of modified Quyu Xiezhuo tang based on routine treatment can markedly improve the renal function and clinical effect,which has high safety and great significance in clinical practice.

    参考文献
    相似文献
    引证文献
引用本文

王丽霞.祛瘀泄浊汤加减联合西药治疗慢性肾功能衰竭临床疗效观察[J].新中医,2017,49(12):52-54

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2017-12-02
  • 出版日期: