Objective：To observe the curative effect of Naoxintong capsules combined with routine therapy for cardiac failure caused by coronary heart disease.Methods：Divided 80 patients with cardiac failure caused by coronary heart disease with qi deficiency and blood stasis syndrome into the treatment group and the control group randomly，40 cases in each group.Both groups receivedroutine western medicine for treatment，while the treatment group additionally received Naoxintong capsules.Both groups received treatment for six months.Quality of life(QOL)score，the level of serum matrix metalloproteinase-2(MMP-2)and left ventricular mass index before and after treatment between the two groups were compared respectively.Results：After treatment，QOL scores in both groups were decreased when compared with those before treatment，differences being significant(P＜0.05)；QOL scores in the treatment group were lower than those in the control group(P＜0.05).MMP-2 levels in both groups were lower than those before treatment，differences being significant(P＜0.05)；serum MMP-2 levels in the treatment group were lower than those in the control group，the difference being significant(P＜0.05).No significance was found in the comparison of left ventricular mass indexes before and after treatment between the two groups(P＞0.05).There was a downward trend of left ventricular mass indexes in the treatment group in comparison to the control group，but there was no significant difference(P＞ 0.05).Conclusion：Long-term administration of Naoxintong capsules combined with routine therapy can improve QOL of patients with cardiac failure caused by coronary heart disease and prevent ventricular remodeling.